(S)-methyl 2-(N-allyl-4-nitrophenylsulfonamido)-3-phenylpropanoate

Base Information

• Chemical Name: (S)-methyl 2-(N-allyl-4-nitrophenylsulfonamido)-3-phenylpropanoate
• CAS No.: 203873-68-1
• Molecular Formula: C₁₉H₂₀N₂O₆S
• Molecular Weight: 404.444
• Mol file: 203873-68-1.mol

Synonyms:(S)-methyl 2-(N-allyl-4-nitrophenylsulfonamido)-3-phenylpropanoate

Chemical Property of (S)-methyl 2-(N-allyl-4-nitrophenylsulfonamido)-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-methyl 2-(N-allyl-4-nitrophenylsulfonamido)-3-phenylpropanoate

There total 4 articles about (S)-methyl 2-(N-allyl-4-nitrophenylsulfonamido)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

allyl bromide (106-95-6) + (S)-methyl 2-(4-nitrophenylsulphonamido)-3-phenylpropanoate (191337-25-4) → (S)-methyl 2-(N-allyl-4-nitrophenylsulfonamido)-3-phenylpropanoate (203873-68-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(97)10766-3

Reference yield:

4-Nitrobenzenesulfonyl chloride (98-74-8) → (S)-methyl 2-(N-allyl-4-nitrophenylsulfonamido)-3-phenylpropanoate (203873-68-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / Et₃N / CH₂Cl₂

2: 100 percent / K₂CO₃ / dimethylformamide

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(97)10766-3

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → (S)-methyl 2-(N-allyl-4-nitrophenylsulfonamido)-3-phenylpropanoate (203873-68-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / triethylamine / CH₂Cl₂ / 16 h

2: 100 percent / K₂CO₃ / dimethylformamide / 16 h

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 1: sulfonylation / 2: Alkylation;

DOI:10.1002/1099-0690(200006)2000:12<2335::AID-EJOC2335>3.0.CO;2-C

upstream raw materials:

allyl bromide

(S)-methyl 2-(4-nitrophenylsulphonamido)-3-phenylpropanoate

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

methyl (2S)-2-amino-3-phenylpropanoate

Downstream raw materials:

(S)-2-allylamino-3-phenyl-propionic acid methyl ester

Boc-(Nall)Phe-OH

(S)-2-(allyl-tert-butoxycarbonylamino)-3-phenylpropionic acid methyl ester

Boc-(Nall)Phe-(Nall)Gly-OEt