Technology Process of <3aS-(3aα,4Z,6aα)>-5-imidazol-4-ylidene>pentanoic acid methyl ester
There total 13 articles about <3aS-(3aα,4Z,6aα)>-5-imidazol-4-ylidene>pentanoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: citric acid; NaHCO3; NaBH3CN / H2O; tetrahydrofuran / 2.5 h / 5 °C / pH 4
2: 1.4 g / HCl / H2O; tetrahydrofuran / 21 h / 25 °C
3: 77 percent / NaHCO3; triethyl phosphite; Pd(OAc)2 / tetrabutylammonium chloride / dimethylformamide; H2O / 2 h / 100 °C
With
hydrogenchloride; palladium diacetate; sodium cyanoborohydride; sodium hydrogencarbonate; citric acid; triethyl phosphite;
tetrabutyl-ammonium chloride;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jo025794+
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 100 percent / triethylamine; 4-(dimethylamino)pyridine / tetrahydrofuran / 2.5 h / 0 °C
2: MeOH; acetyl chloride / toluene / 1 h / 0 °C
3: citric acid; NaHCO3; NaBH3CN / H2O; tetrahydrofuran / 2.5 h / 5 °C / pH 4
4: 1.4 g / HCl / H2O; tetrahydrofuran / 21 h / 25 °C
5: 77 percent / NaHCO3; triethyl phosphite; Pd(OAc)2 / tetrabutylammonium chloride / dimethylformamide; H2O / 2 h / 100 °C
With
hydrogenchloride; methanol; dmap; palladium diacetate; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; acetyl chloride; citric acid; triethyl phosphite;
tetrabutyl-ammonium chloride;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo025794+
