Technology Process of N-(1-benzyl-4,4-difluoro-2,2-dimethylbut-3-en-1-ylidene)-4-methylbenzenesulfonamide
There total 4 articles about N-(1-benzyl-4,4-difluoro-2,2-dimethylbut-3-en-1-ylidene)-4-methylbenzenesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5,5-difluoro-3,3-dimethyl-1-phenylpent-4-en-2-one; toluene-4-sulfonamide;
With
triethylamine;
at 0 ℃;
for 0.0833333h;
Inert atmosphere;
With
titanium tetrachloride;
at 0 ℃;
for 24h;
Reflux;
Inert atmosphere;
DOI:10.1055/s-0033-1340857
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalic acid / dichloromethane; water / 1 h / 20 °C / Inert atmosphere
2.1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.25 h / -78 - 20 °C / Molecular sieve; Inert atmosphere
2.2: 10 h / Inert atmosphere
3.1: triethylamine / 0.08 h / 0 °C / Inert atmosphere
3.2: 24 h / 0 °C / Reflux; Inert atmosphere
With
oxalic acid; triethylamine; Hexamethylphosphorous triamide;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1055/s-0033-1340857
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium; diisopropylamine / diethyl ether; hexane / 2.17 h / -78 - 0 °C / Inert atmosphere
1.2: 12.25 h / -78 - 20 °C / Inert atmosphere
2.1: oxalic acid / dichloromethane; water / 1 h / 20 °C / Inert atmosphere
3.1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.25 h / -78 - 20 °C / Molecular sieve; Inert atmosphere
3.2: 10 h / Inert atmosphere
4.1: triethylamine / 0.08 h / 0 °C / Inert atmosphere
4.2: 24 h / 0 °C / Reflux; Inert atmosphere
With
n-butyllithium; oxalic acid; triethylamine; diisopropylamine; Hexamethylphosphorous triamide;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; water;
DOI:10.1055/s-0033-1340857
