21353-16-2

Usage

InChI:InChI=1/C14H10O3/c1-8-7-13(16)17-14-9(8)5-6-10-11(14)3-2-4-12(10)15/h2-7,15H,1H3

Upstream product

• 628-13-7 pyridine hydrochloride 
• 83-56-7 1,5-dihydroxynaphthalene 
• 141-97-9 ethyl acetoacetate 
• 105-45-3 acetoacetic acid methyl ester 
• 3588-80-5 5-methoxynaphthalen-1-ol 
• 7647-01-0 hydrogenchloride 
• 114397-85-2 1,5-bis-acetoacetyloxy-naphthalene 
• 674-82-8 4-methyleneoxetan-2-one 

Downstream Products

• 21353-27-5 7-methyl-2-phenyl-2,3-dihydro-1H-pyrano[2',3':5,6]naphtho[2,1-e][1,3]oxazin-9-one 
• 21353-25-3 2-benzyl-7-methyl-2,3-dihydro-1H-pyrano[2',3':5,6]naphtho[2,1-e][1,3]oxazin-9-one 
• 189514-40-7 7-hydroxy-4-methyl-8-(phenyliminomethyl)benzo[h]chromen-2-one 
• 1231948-23-4 7-benzyloxy-4-methyl-benzo[h]chromen-2-one 
• 1231948-22-3 4-methyl-7-(1-phenyl-ethoxy)-benzo[h]chromen-2-one 
• 1323444-51-4 (E)-8-acetyl-1-methyl-5-(3-oxo-3-p-tolylprop-1-enyl)chromeno[8,7-h]chromene-3,9-dione 
• 1323444-60-5 (E)-methyl 7-methyl-3,9-dioxo-11-(3-oxo-3-phenylprop-1-enyl)-3,9-dihydrochromeno[8,7-h]chromene-2-carboxylate 
• 1323444-59-2 (E)-ethyl 7-methyl-3,9-dioxo-11-(3-oxo-3-phenylprop-1-enyl)-3,9-dihydrochromeno[8,7-h]chromene-2-carboxylate 
• 1323444-53-6 (E)-methyl 7-methyl-3,9-dioxo-11-(3-oxo-3-p-tolylprop-1-enyl)-3,9-dihydrochromeno[8,7-h]chromene-2-carboxylate 
• 1323444-52-5 (E)-ethyl 7-methyl-3,9-dioxo-11-(3-oxo-3-p-tolylprop-1-enyl)-3,9-dihydrochromeno[8,7-h]chromene-2-carboxylate 
• 1259925-35-3 (E)-7-hydroxy-4-methyl-2-oxo-10-(3-oxo-3-p-tolylprop-1-enyl)-2H-benzo[h]chromene-8-carbaldehyde 
• 1259925-34-2 7-hydroxy-4-methyl-2-oxo-10-(3-oxo-3-phenylpropenyl)-2H-benzo[h]chromene-8-carbaldehyde 
• 941584-65-2 1-(4-methoxyphenyl)-7-methyl-1,2,3,9-tetrahydrochromeno[8,7-h]chromene-3,9-dione 
• 1374677-29-8 N-(3,4-dimethylbenzyl)-2-(4-methyl-2-oxo-2H-benzo[h]chromen-7-yloxy)acetamide 

Relevant academic research and scientific papers

Discovery and synthesis of novel substituted benzocoumarins as orally active lipid modulating agents

The synthesis of a series of benzocoumarin keto-enamine schiff bases is reported. The novel compounds were evaluated for their antihyperlipidemic activity in the hyperlipidemic hamster model. The compound 11 at a dose of 10 mg/kg body weight significantly

Synthesis and anti-cancer activity of naphthopyrone derivatives

Coumarins are naturally evolving molecules that have a wide variety of activities. In medical chemistry and chemical biology, their structural and physicochemical properties make them a suitable scaffold. Herein, we designed and synthesized novel coumarin analogues-7-O-substituted pyridyl-4-methyl naphthopyrone derivatives and initially evaluated their anti-cancer activity. RTCA profiling reveals that compounds 6, 7 and 8, in particular 7, possess stronger in vitro cytotoxicity for A549 cells. All synthesized compounds have been characterized by 1H NMR spectra, elemental analysis, and mass spectrometry.

Synthesis of 2H-4,8-dimethylthieno[2′,3′: 5,6]naphtho[1,2-b]pyran-2-one with potential photobiological activity to DNA

2H-4,8-Dimethylthieno[2′,3′:5,6]naphtho[1,2-b]pyran-2-one (7), a potential photobiological agent, was synthesized in six steps starting from commercially available 1,5-naphthalenediol. A Newman-Kwart rearrangement of naphthopyrone 2 and an unusual S-Claisen rearrangement of naphthopyrone 5 are the key steps. The structures of 7 and its precursors were fully characterized.

MnSb2O6-chitosan nanocomposite: An efficient catalyst for the synthesis of coumarins via Pechmann reaction

In this work, MnSb2O6-chitosan nanocomposites were synthesized and have been employed in Pechmann condensation for the synthesis of coumarin derivatives. MnSb2O6-chitosan nanocomposites were characterized by Fou

A naphtho pyrone compound and its preparation method and application

The invention relates to naphthopyrone compounds, and a preparation method and application thereof, belonging to the field of pharmaceutical chemistry. The six naphthopyrone compounds have the advantages of simple preparation process, simple raw materials, convenient after-treatment, high yield and high purity (up to 98% or above), and the structure can be verified through nuclear magnetism and mass spectroscopy. After the six naphthopyrone compounds are used for preparing antineoplastic drugs and the obtained antineoplastic drugs are subjected to anticancer activity research on A549 cells (human non-small cell lung cancer cells), the research result on the apoptosis by the real-time cell analysis technique (RTCA) proves that the compounds L2 and L3 have strong killing actions on the A549 cells, the compound L1 has weaker killing actions, and the compounds L4, L5 and L5 have the weakest killing actions. Therefore, the invention has substantial meanings for research into screening of the antineoplastic drugs of the compounds.

Silica supported boric tri-sulfuric anhydride as a novel and efficient catalyst for solvent-free synthesis of coumarins via Pechmann condensation

It is found that silica supported boric trisulfuric anhydride (BTSA.SiO2) is a novel, suitable and versatile catalyst for efficient and clean synthesis of coumarins via Pechmann cyclocondensation under mild and solvent-free conditions. Different kinds of

Synthesis and evaluation of anti-thrombotic activity of benzocoumarin amide derivatives

A series of novel benzocoumarin amide derivatives have been synthesized and evaluated for their anti-thrombotic activity. Amongst these, compounds 5, 7 and 8 exhibited promising anti-thrombotic profile in an established model of mouse thrombosis. Hence, c

Synthesis and anti-inflammatory activity of novel biscoumarin-chalcone hybrids

A series of synthesized novel biscoumarin-chalcone hybrids were evaluated for their anti-inflammatory and antioxidant activity. The tested compounds significantly inhibit the carrageenin induced paw oedema in albino rats and also exhibit important scaveng

Neo-tanshinlactone inspired synthesis, in vitro evaluation of novel substituted benzocoumarin derivatives as potent anti-breast cancer agents

A small library of novel benzocoumarin derivatives based on naturally occurring neo-tanshinlactone scaffold was constructed and their antiproliferative activities against breast cancer cells MCF-7 and MDA-MB-231 were evaluated. A number of derivatives sho

Synthesis of novel benzocoumarin derivatives as lipid lowering agents

A series of novel benzocoumarin derivatives were synthesized and evaluated for their in vivo anti-dyslipidemic and in vitro antioxidant activities. Preliminary screening indicates compound 4 as potential lead with significant lipid lowering and antioxidant activities. The study revealed that such attempts on benzocoumarin-based pharmacophores which is a biologically important scaffold might result in identification of new lead for anti-dyslipidemia.