5-hydroxy-3-oxo-7-(4-tert-butyldimethylsilyloxyphenyl) heptanoic acid methyl ester

Base Information

Chemical Name:5-hydroxy-3-oxo-7-(4-tert-butyldimethylsilyloxyphenyl) heptanoic acid methyl ester
CAS No.:856433-44-8
Molecular Formula:C₂₀H₃₂O₅Si
Molecular Weight:380.557
Hs Code.:

Synonyms:5-hydroxy-3-oxo-7-(4-tert-butyldimethylsilyloxyphenyl) heptanoic acid methyl ester

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Chemical Property of 5-hydroxy-3-oxo-7-(4-tert-butyldimethylsilyloxyphenyl) heptanoic acid methyl ester

Chemical Property:

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Technology Process of 5-hydroxy-3-oxo-7-(4-tert-butyldimethylsilyloxyphenyl) heptanoic acid methyl ester

There total 1 articles about 5-hydroxy-3-oxo-7-(4-tert-butyldimethylsilyloxyphenyl) heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74590-73-1
1,3-bis(trimethylsiloxy)-1-methoxybuta-1,3-diene

: 147974-20-7
3-[4-(tert-butyl-dimethyl-silanyloxy)phenyl]propionaldehyde

: 856433-44-8
5-hydroxy-3-oxo-7-(4-tert-butyldimethylsilyloxyphenyl) heptanoic acid methyl ester

Guidance literature:: With ytterbium(III) triflate; In dichloromethane; at -78 ℃; for 3h;
DOI:10.1016/j.tet.2005.04.011

Reference yield: 92.0%

: 856433-44-8
5-hydroxy-3-oxo-7-(4-tert-butyldimethylsilyloxyphenyl) heptanoic acid methyl ester

: 123-11-5
4-methoxy-benzaldehyde

: (2R,3S,6R)-6-[2-(4-Hydroxy-phenyl)-ethyl]-2-(4-methoxy-phenyl)-4-oxo-tetrahydro-pyran-3-carboxylic acid methyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1016/j.tet.2005.04.011

Reference yield:

: 856433-44-8
5-hydroxy-3-oxo-7-(4-tert-butyldimethylsilyloxyphenyl) heptanoic acid methyl ester

: (+/-)-4-(2-(tetrahydro-6-(4-methoxyphenyl)-2H-pyran-2-yl)ethyl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 20 °C

2: 60 percent / hydrogen peroxide; lithium hydroxide / tetrahydrofuran; H₂O / 2 h / 60 °C

3: 100 percent / BF₃*Et₂O / CH₂Cl₂ / 0.33 h / 20 °C

4: 100 percent / hydrogen; Raney nickel / ethanol / 18 h / 35 °C

With lithium hydroxide; boron trifluoride diethyl etherate; hydrogen; dihydrogen peroxide; nickel; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; 1: Maitland-Japp reaction;
DOI:10.1016/j.tet.2005.04.011