2-tert-bytyl-(4R)-[2-(diphenyl-phosphinothioyl)-phenyl]-4,5-dihydro-oxazole

Base Information

Chemical Name:2-tert-bytyl-(4R)-[2-(diphenyl-phosphinothioyl)-phenyl]-4,5-dihydro-oxazole
CAS No.:861890-07-5
Molecular Formula:C₂₅H₂₆NOPS
Molecular Weight:419.527
Hs Code.:

Synonyms:2-tert-bytyl-(4R)-[2-(diphenyl-phosphinothioyl)-phenyl]-4,5-dihydro-oxazole

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Chemical Property of 2-tert-bytyl-(4R)-[2-(diphenyl-phosphinothioyl)-phenyl]-4,5-dihydro-oxazole

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Technology Process of 2-tert-bytyl-(4R)-[2-(diphenyl-phosphinothioyl)-phenyl]-4,5-dihydro-oxazole

There total 4 articles about 2-tert-bytyl-(4R)-[2-(diphenyl-phosphinothioyl)-phenyl]-4,5-dihydro-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 861890-06-4
2-hydroxy-(1R)-[2-(diphenyl-phosphinothioyl)-phenyl]-ethylamine

: 3282-30-2
pivaloyl chloride

: 861890-07-5
2-tert-bytyl-(4R)-[2-(diphenyl-phosphinothioyl)-phenyl]-4,5-dihydro-oxazole

Guidance literature:: 2-hydroxy-(1R)-[2-(diphenyl-phosphinothioyl)-phenyl]-ethylamine; pivaloyl chloride; With triethylamine; In dichloromethane; at 0 ℃; for 2h;

With methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tet.2005.03.111

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 861890-07-5
2-tert-bytyl-(4R)-[2-(diphenyl-phosphinothioyl)-phenyl]-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

2.1: n-BuLi / diethyl ether; hexane / -78 - 20 °C

2.2: diethyl ether; hexane / -78 - 20 °C

2.3: 65 percent / sulfur / diethyl ether; hexane / 1 h / 20 °C

3.1: HCl / methanol / 4 h / 50 °C

4.1: triethylamine / CH₂Cl₂ / 2 h / 0 °C

4.2: 47 percent / triethylamine; N,N-diisopropylethylamine; methanesulfonyl chloride / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; n-butyllithium; triethylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;
DOI:10.1016/j.tet.2005.03.111

Reference yield:

: 854691-01-3
(tert-butyl-dimethyl-silanyl)-[2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amine

: 861890-07-5
2-tert-bytyl-(4R)-[2-(diphenyl-phosphinothioyl)-phenyl]-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / diethyl ether; hexane / -78 - 20 °C

1.2: diethyl ether; hexane / -78 - 20 °C

1.3: 65 percent / sulfur / diethyl ether; hexane / 1 h / 20 °C

2.1: HCl / methanol / 4 h / 50 °C

3.1: triethylamine / CH₂Cl₂ / 2 h / 0 °C

3.2: 47 percent / triethylamine; N,N-diisopropylethylamine; methanesulfonyl chloride / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; n-butyllithium; triethylamine; In methanol; diethyl ether; hexane; dichloromethane;
DOI:10.1016/j.tet.2005.03.111