2-[3-(acetylamino)propoxy]-4-[(tertbutoxycarbonyl)amino]benzoic acid

Base Information

• Chemical Name: 2-[3-(acetylamino)propoxy]-4-[(tertbutoxycarbonyl)amino]benzoic acid
• CAS No.: 1333127-07-3
• Molecular Formula: C₁₇H₂₄N₂O₆
• Molecular Weight: 352.387
• Mol file: 1333127-07-3.mol

Synonyms:2-[3-(acetylamino)propoxy]-4-[(tertbutoxycarbonyl)amino]benzoic acid

Chemical Property of 2-[3-(acetylamino)propoxy]-4-[(tertbutoxycarbonyl)amino]benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-[3-(acetylamino)propoxy]-4-[(tertbutoxycarbonyl)amino]benzoic acid

There total 3 articles about 2-[3-(acetylamino)propoxy]-4-[(tertbutoxycarbonyl)amino]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid (184033-42-9) + N-(3-chloro-propyl)-acetamide (14091-77-1) → 2-[3-(acetylamino)propoxy]-4-[(tertbutoxycarbonyl)amino]benzoic acid (1333127-07-3)

Guidance literature:

With potassium carbonate; at 110 ℃; for 1h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 2-[3-(acetylamino)propoxy]-4-[(tertbutoxycarbonyl)amino]benzoic acid (1333127-07-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane; water / 24 h

2: potassium carbonate / 1 h / 110 °C

With potassium carbonate; sodium hydroxide; In 1,4-dioxane; water;

Reference yield:

4-Aminosalicylic acid (65-49-6) → 2-[3-(acetylamino)propoxy]-4-[(tertbutoxycarbonyl)amino]benzoic acid (1333127-07-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane; water / 24 h

2: potassium carbonate / 1 h / 110 °C

With potassium carbonate; sodium hydroxide; In 1,4-dioxane; water;

upstream raw materials:

di-tert-butyl dicarbonate

4-Aminosalicylic acid

4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid

N-(3-chloro-propyl)-acetamide

Downstream raw materials:

2-[3-(acetylamino)propoxy]-4-aminobenzoic acid

N-(5-chloropyridine-2-yl)-2-{[4-trifluoroacetyl(methyl)amino]-2-[3-(trifluoroacetylamino)propoxy]phenyl-carbonylamino}benzamide

N-(5-chloropyridine-2-yl)-2-[4-methylamino-2-(3-aminopropoxy)-phenylcarbonylamino]-benzamide

N-(5-chloropyridine-2-yl)-2-[4-(ethaneimidoylmethylamino)-2-(3-aminopropoxy)phenylcarbonyl-amino]benzamide