2-(3,4-dimethoxyphenyl)-5-(4-hydroxy-4-phenylpiperidin-1-yl)-2-isopropylpentanenitrile

Base Information

Chemical Name:2-(3,4-dimethoxyphenyl)-5-(4-hydroxy-4-phenylpiperidin-1-yl)-2-isopropylpentanenitrile
CAS No.:1616284-83-3
Molecular Formula:C₂₇H₃₆N₂O₃
Molecular Weight:436.594
Hs Code.:

Synonyms:2-(3,4-dimethoxyphenyl)-5-(4-hydroxy-4-phenylpiperidin-1-yl)-2-isopropylpentanenitrile

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Chemical Property of 2-(3,4-dimethoxyphenyl)-5-(4-hydroxy-4-phenylpiperidin-1-yl)-2-isopropylpentanenitrile

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Technology Process of 2-(3,4-dimethoxyphenyl)-5-(4-hydroxy-4-phenylpiperidin-1-yl)-2-isopropylpentanenitrile

There total 3 articles about 2-(3,4-dimethoxyphenyl)-5-(4-hydroxy-4-phenylpiperidin-1-yl)-2-isopropylpentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 40807-61-2
4-hydroxy-4-phenylpiperidin

: 27487-83-8
2-(3,4-dimethoxyphenyl)-2-isopropyl-2-(3-chloropropyl)acetonitrile

: 1616284-83-3
2-(3,4-dimethoxyphenyl)-5-(4-hydroxy-4-phenylpiperidin-1-yl)-2-isopropylpentanenitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 12h;
DOI:10.1016/j.bmcl.2014.05.022

Reference yield:

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 1616284-83-3
2-(3,4-dimethoxyphenyl)-5-(4-hydroxy-4-phenylpiperidin-1-yl)-2-isopropylpentanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 20 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 1.33 h / -78 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C

With n-butyllithium; potassium carbonate; diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.05.022

Reference yield:

: 20850-49-1
2-(3,4-dimethoxyphenyl)-3-methylbutyronitrile

: 1616284-83-3
2-(3,4-dimethoxyphenyl)-5-(4-hydroxy-4-phenylpiperidin-1-yl)-2-isopropylpentanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 1.33 h / -78 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C

With n-butyllithium; potassium carbonate; diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.05.022