5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)-N₄-(3-nitrophenyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: 5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)-N₄-(3-nitrophenyl)pyrimidine-2,4-diamine
• CAS No.: 1616380-52-9
• Molecular Formula: C₂₀H₂₀FN₅O₅
• Molecular Weight: 429.408

Synonyms:5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)-N₄-(3-nitrophenyl)pyrimidine-2,4-diamine

Chemical Property of 5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)-N₄-(3-nitrophenyl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of 5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)-N₄-(3-nitrophenyl)pyrimidine-2,4-diamine

There total 5 articles about 5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)-N₄-(3-nitrophenyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(2-methoxyethoxy)methoxy]aniline + 2-chloro-N4-(3-nitrophenyl)-5-fluoro-4-pyrimidineamine (575474-26-9) → 5-fluoro-N2-(4-((2-methoxyethoxy)methoxy)phenyl)-N4-(3-nitrophenyl)pyrimidine-2,4-diamine (1616380-52-9)

Guidance literature:

With acetic acid; In ethanol; for 24h; Reflux;

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → 5-fluoro-N2-(4-((2-methoxyethoxy)methoxy)phenyl)-N4-(3-nitrophenyl)pyrimidine-2,4-diamine (1616380-52-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4.5 h / 0 - 20 °C

2: palladium on activated charcoal; hydrogen / methanol / 20 °C / Inert atmosphere

3: acetic acid / ethanol / 24 h / Reflux

With palladium on activated charcoal; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane;

Reference yield:

1-[(2-methoxyethoxy)methoxy]-4-nitrobenzene (198829-77-5) → 5-fluoro-N2-(4-((2-methoxyethoxy)methoxy)phenyl)-N4-(3-nitrophenyl)pyrimidine-2,4-diamine (1616380-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol / 20 °C / Inert atmosphere

2: acetic acid / ethanol / 24 h / Reflux

With palladium on activated charcoal; hydrogen; acetic acid; In methanol; ethanol;

upstream raw materials:

2-chloro-N₄-(3-nitrophenyl)-5-fluoro-4-pyrimidineamine

4-nitro-aniline

4-nitro-phenol

1-[(2-methoxyethoxy)methoxy]-4-nitrobenzene

Downstream raw materials:

N₄-(3-aminophenyl)-5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)pyrimidine-2,4-diamine

N-(3-((5-fluoro-2-((4-((2-methoxyethoxy)methoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

N-(3-((5-fluoro-2-((4-hydroxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

N-(3-((5-fluoro-2-((4-hydroxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)-2,3-dihydroxypropanamide

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