methyl (5S,7R,8R)-9-(tert-butyldiphenylsilyloxy)-5,7-di(benzoyloxy)-8-iodonon-3(Z)-enoate

Base Information

Chemical Name:methyl (5S,7R,8R)-9-(tert-butyldiphenylsilyloxy)-5,7-di(benzoyloxy)-8-iodonon-3(Z)-enoate
CAS No.:358395-63-8
Molecular Formula:C₄₀H₄₃IO₇Si
Molecular Weight:790.767
Hs Code.:

Synonyms:methyl (5S,7R,8R)-9-(tert-butyldiphenylsilyloxy)-5,7-di(benzoyloxy)-8-iodonon-3(Z)-enoate

Suppliers and Price of methyl (5S,7R,8R)-9-(tert-butyldiphenylsilyloxy)-5,7-di(benzoyloxy)-8-iodonon-3(Z)-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (5S,7R,8R)-9-(tert-butyldiphenylsilyloxy)-5,7-di(benzoyloxy)-8-iodonon-3(Z)-enoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl (5S,7R,8R)-9-(tert-butyldiphenylsilyloxy)-5,7-di(benzoyloxy)-8-iodonon-3(Z)-enoate

There total 7 articles about methyl (5S,7R,8R)-9-(tert-butyldiphenylsilyloxy)-5,7-di(benzoyloxy)-8-iodonon-3(Z)-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-Butyl-[(R)-2-((3aS,5R,6aS)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-2-iodo-ethoxy]-diphenyl-silane

: 358395-63-8
methyl (5S,7R,8R)-9-(tert-butyldiphenylsilyloxy)-5,7-di(benzoyloxy)-8-iodonon-3(Z)-enoate

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / ZnCl₂ / 0.5 h / -20 °C

2: 88 percent / pyridine / 20 °C

3: 100 percent / HgO; HgCl₂ / acetone; H₂O / Heating

4: 74 percent / KHMDS / tetrahydrofuran / 1 h / -80 - 20 °C

5: Jones reagent / acetone / 2 h / -10 - 20 °C

6: 401 mg / diethyl ether

With jones reagent; potassium hexamethylsilazane; mercury dichloride; mercury(II) oxide; zinc(II) chloride; In tetrahydrofuran; pyridine; diethyl ether; water; acetone;
DOI:10.1016/S0040-4020(03)00258-8

Reference yield:

: 358395-61-6
(2S,4R,5R)-6-(tert-butyldiphenylsilyloxy)-2,4-di(benzoyloxy)-5-iodohexanal

: 358395-63-8
methyl (5S,7R,8R)-9-(tert-butyldiphenylsilyloxy)-5,7-di(benzoyloxy)-8-iodonon-3(Z)-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / KHMDS / tetrahydrofuran / 1 h / -80 - 20 °C

2: Jones reagent / acetone / 2 h / -10 - 20 °C

3: 401 mg / diethyl ether

With jones reagent; potassium hexamethylsilazane; In tetrahydrofuran; diethyl ether; acetone;
DOI:10.1016/S0040-4020(03)00258-8

Reference yield:

: 358395-59-2
(2S,4R,5R)-6-(tert-butyldiphenylsilyloxy)-1,1-diethylthio-5-iodohexane-2,4-diol

: 358395-63-8
methyl (5S,7R,8R)-9-(tert-butyldiphenylsilyloxy)-5,7-di(benzoyloxy)-8-iodonon-3(Z)-enoate

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / pyridine / 20 °C

2: 100 percent / HgO; HgCl₂ / acetone; H₂O / Heating

3: 74 percent / KHMDS / tetrahydrofuran / 1 h / -80 - 20 °C

4: Jones reagent / acetone / 2 h / -10 - 20 °C

5: 401 mg / diethyl ether

With jones reagent; potassium hexamethylsilazane; mercury dichloride; mercury(II) oxide; In tetrahydrofuran; pyridine; diethyl ether; water; acetone;
DOI:10.1016/S0040-4020(03)00258-8