N-(2-chloro-5-(2-(methylamino)-6-quinolinyl)-3-pyridinyl)-4-methoxybenzenesulfonamide

Base Information

Chemical Name:N-(2-chloro-5-(2-(methylamino)-6-quinolinyl)-3-pyridinyl)-4-methoxybenzenesulfonamide
CAS No.:1201842-67-2
Molecular Formula:C₂₂H₁₉ClN₄O₃S
Molecular Weight:454.937
Hs Code.:

Synonyms:N-(2-chloro-5-(2-(methylamino)-6-quinolinyl)-3-pyridinyl)-4-methoxybenzenesulfonamide

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Chemical Property of N-(2-chloro-5-(2-(methylamino)-6-quinolinyl)-3-pyridinyl)-4-methoxybenzenesulfonamide

Chemical Property:

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Technology Process of N-(2-chloro-5-(2-(methylamino)-6-quinolinyl)-3-pyridinyl)-4-methoxybenzenesulfonamide

There total 5 articles about N-(2-chloro-5-(2-(methylamino)-6-quinolinyl)-3-pyridinyl)-4-methoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1112983-23-9
N-(2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-4-methoxybenzenesulfonamide

: 1201845-11-5
6-bromo-N-methylquinoline-2-amine

: 1201842-67-2
N-(2-chloro-5-(2-(methylamino)-6-quinolinyl)-3-pyridinyl)-4-methoxybenzenesulfonamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; at 75 ℃; for 16h;

Reference yield:

: 588729-99-1
3-amino-5-bromo-2-chloropyridine

: 1201842-67-2
N-(2-chloro-5-(2-(methylamino)-6-quinolinyl)-3-pyridinyl)-4-methoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol / 16 h / 75 °C

With potassium acetate; sodium carbonate; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

: 1810-71-5
6-bromo-2-chloroquinoline

: 1201842-67-2
N-(2-chloro-5-(2-(methylamino)-6-quinolinyl)-3-pyridinyl)-4-methoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 1.5 h / 100 °C / microwave irradiation

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol / 16 h / 75 °C

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol;