1-benzyl-6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-isoquinoline

Base Information

• Chemical Name: 1-benzyl-6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-isoquinoline
• CAS No.: 47545-34-6
• Molecular Formula: C₂₄H₂₅NO₂
• Molecular Weight: 359.468
• Mol file: 47545-34-6.mol

Synonyms:1-benzyl-6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-isoquinoline

Chemical Property of 1-benzyl-6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-isoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-isoquinoline

There total 7 articles about 1-benzyl-6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-benzyl-6-benzyloxy-7-methoxy-3,4-dihydroisoquinoline (288083-64-7) → 1-benzyl-6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-isoquinoline (47545-34-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h;

DOI:10.1016/S0968-0896(00)00027-4

Reference yield: 42.0%

methanol (67-56-1) + N-(3-benzyloxy-4-methoxyphenylethyl)-phenylacetamide (16575-33-0) → 1-benzyl-6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-isoquinoline (47545-34-6) + 1-benzyl-6-benzyloxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline (55161-46-1)

Guidance literature:

N-(3-benzyloxy-4-methoxyphenylethyl)-phenylacetamide; With trichlorophosphate; In dichloromethane; for 3h; Heating;

methanol; With sodium tetrahydroborate; at -40 ℃; for 4h;

DOI:10.1016/S0968-0896(00)00027-4

Reference yield: 40.0%

1-benzyl-6-benzyloxy-7-methoxy-3,4-dihydroisoquinoline (288083-64-7) + isopropyl alcohol (67-63-0,8013-70-5) → 1-benzyl-6-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-isoquinoline (47545-34-6) + (1-benzyl-6-benzyloxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-phosphonic acid diisopropyl ester

Guidance literature:

1-benzyl-6-benzyloxy-7-methoxy-3,4-dihydroisoquinoline; isopropyl alcohol; With trichlorophosphate; for 4h; Heating;

With sodium tetrahydroborate; at 20 ℃; for 15h;

DOI:10.1016/S0960-894X(00)00262-6

upstream raw materials:

methanol

1-benzyl-6-benzyloxy-7-methoxy-3,4-dihydroisoquinoline

N-(3-benzyloxy-4-methoxyphenylethyl)-phenylacetamide

ethanol

Downstream raw materials:

1-benzyl-6-benzyloxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline

1-benzyl-6-hydroxy-7-methoxy-N-methyl-1,2,3,4-tetrahydroisoquinoline