6--2,4-dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidine

Base Information

• Chemical Name: 6--2,4-dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidine
• CAS No.: 175791-63-6
• Molecular Formula: C₂₂H₂₁N₃O₆S
• Molecular Weight: 455.491
• Mol file: 175791-63-6.mol

Synonyms:6--2,4-dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidine

Chemical Property of 6--2,4-dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6--2,4-dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidine

There total 4 articles about 6--2,4-dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-methoxy-benzaldehyde (123-11-5) + 2,4-Dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidine (155826-81-6) → 6--2,4-dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidine (175791-63-6)

Guidance literature:

With tert.-butyl lithium; In tetrahydrofuran; pentane; 1.) -78 deg C, 0.5 h, 2.) -78 deg C, 2 h;

DOI:10.1039/p19960000459

Reference yield:

2,4-dimethoxy-7H-pyrrolo<2,3-d>pyrimidine (90057-09-3) → 6--2,4-dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidine (175791-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / NaH / tetrahydrofuran / 1.) r.t., 1 h, 2.) r.t., 1 h

2: 79 percent / t-BuLi / tetrahydrofuran; pentane / 1.) -78 deg C, 0.5 h, 2.) -78 deg C, 2 h

With tert.-butyl lithium; sodium hydride; In tetrahydrofuran; pentane;

DOI:10.1039/p19960000459

Reference yield:

benzenesulfonyl chloride (98-09-9) → 6--2,4-dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidine (175791-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / NaH / tetrahydrofuran

2: 1.) t-BuLi / 1.) THF

With tert.-butyl lithium; sodium hydride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)76660-3

upstream raw materials:

4-methoxy-benzaldehyde

2,4-Dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidine

2,4-dimethoxy-7H-pyrrolo<2,3-d>pyrimidine

benzenesulfonyl chloride

Downstream raw materials:

2,4-Dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

6-(4-hydroxybenzoyl)-5-(4-hydroxyphenyl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

2,4-Dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

5-Iodo-2,4-dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone