2-(4-Chlorophenyl)pyridin-3-ol

Base Information

• Chemical Name: 2-(4-Chlorophenyl)pyridin-3-ol
• CAS No.: 42470-80-4
• Molecular Formula: C₁₁H₈ClNO
• Molecular Weight: 205.644
• DSSTox Substance ID: DTXSID70575952
• Nikkaji Number: J3.535.884F
• Wikidata: Q82465436
• Mol file: 42470-80-4.mol

Synonyms:2-(4-chlorophenyl)pyridin-3-ol;42470-80-4;2-(4-CHLOROPHENYL)-3-HYDROXYPYRIDINE;DTXSID70575952;MFCD18312072;AKOS017557261;2-(4'-chlorophenyl)-3-hydroxypyridine;2-(4-Chlorophenyl)-3-hydroxypyridine, 95%

Chemical Property of 2-(4-Chlorophenyl)pyridin-3-ol

Chemical Property:

• Boiling Point: 403.9±30.0 °C(Predicted)
• Density: 1.298±0.06 g/cm3(Predicted)
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 205.0294416
• Heavy Atom Count: 14
• Complexity: 180

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)C2=CC=C(C=C2)Cl)O

Technology Process of 2-(4-Chlorophenyl)pyridin-3-ol

There total 7 articles about 2-(4-Chlorophenyl)pyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C13H12ClNO2 → 2-(4-chlorophenyl)pyridin-3-ol (42470-80-4)

Guidance literature:

C₁₃H₁₂ClNO₂; With hydrogenchloride; In tetrahydrofuran; ethanol; water; at 60 ℃; for 2h;

With sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water;

DOI:10.1021/acs.orglett.5b00276

Reference yield: 74.0%

3-HYDROXYPYRIDINE (109-00-2) + 4-chloro-aniline (106-47-8) → 2-(4-chlorophenyl)pyridin-3-ol (42470-80-4)

Guidance literature:

4-chloro-aniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

3-HYDROXYPYRIDINE; With hydrogenchloride; titanium(III) chloride; In water; for 0.416667h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.joc.6b00894

Reference yield: 69.0%

3-HYDROXYPYRIDINE (109-00-2) + p-chlorobenzenediazonium chloride (2028-74-2) → 2-(4-chlorophenyl)pyridin-3-ol (42470-80-4)

Guidance literature:

With hydrogenchloride; titanium(III) chloride; In water; at 20 ℃; for 0.416667h; Inert atmosphere;

DOI:10.1016/j.tet.2018.05.089

upstream raw materials:

(4-chlorophenyl)(furan-2-yl)methanone

ammonium acetate

4-Chlorophenylboronic acid

3-HYDROXYPYRIDINE