3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:191285-80-0
Molecular Formula:C₃₁H₄₆Cl₂N₂O₈Si
Molecular Weight:673.706
Hs Code.:

3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Synonyms:3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Property of 3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

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Technology Process of 3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 6 articles about 3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 191285-79-7
3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-aminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

: 191285-80-0
3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1016/S0968-0896(97)00024-2

Reference yield:

: 5197-62-6
2-[2-(chloroethoxy)ethoxy]ethanol

: 191285-80-0
3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / DMF / 17 h / Heating

2: 90 percent / Jones reagent / acetone / 1 h

3: 1.) carbonyldiimidazole, 2.) pyridine / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, RT, 48 h

4: 4 h / Heating

5: 41 percent / ammonium formate / ethanol / 72 h / 40 °C

6: 71 percent / 40percent aq. methylamine / 5 h / Ambient temperature

7: 85 percent / aq. K₂CO₃ / tetrahydrofuran / 2 h / 0 °C

With pyridine; jones reagent; ammonium formate; potassium carbonate; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; methylamine; In tetrahydrofuran; ethanol; acetone;
DOI:10.1016/S0968-0896(97)00024-2

Reference yield:

: 75001-09-1
2-(2-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)ethoxy)acetic acid

: 191285-80-0
3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) carbonyldiimidazole, 2.) pyridine / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, RT, 48 h

2: 4 h / Heating

3: 41 percent / ammonium formate / ethanol / 72 h / 40 °C

4: 71 percent / 40percent aq. methylamine / 5 h / Ambient temperature

5: 85 percent / aq. K₂CO₃ / tetrahydrofuran / 2 h / 0 °C

With pyridine; ammonium formate; potassium carbonate; 1,1'-carbonyldiimidazole; methylamine; In tetrahydrofuran; ethanol;
DOI:10.1016/S0968-0896(97)00024-2