3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-aminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-aminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:191285-79-7
Molecular Formula:C₂₆H₃₈Cl₂N₂O₆Si
Molecular Weight:573.589
Hs Code.:

Synonyms:3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-aminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Property of 3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-aminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

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Technology Process of 3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-aminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 6 articles about 3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-aminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 191285-72-0
3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-phthalimidoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

: 191285-79-7
3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-aminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With methylamine; for 5h; Ambient temperature;
DOI:10.1016/S0968-0896(97)00024-2

Reference yield:

: 5197-62-6
2-[2-(chloroethoxy)ethoxy]ethanol

: 191285-79-7
3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-aminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / DMF / 17 h / Heating

2: 90 percent / Jones reagent / acetone / 1 h

3: 1.) carbonyldiimidazole, 2.) pyridine / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, RT, 48 h

4: 4 h / Heating

5: 41 percent / ammonium formate / ethanol / 72 h / 40 °C

6: 71 percent / 40percent aq. methylamine / 5 h / Ambient temperature

With pyridine; jones reagent; ammonium formate; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; methylamine; In ethanol; acetone;
DOI:10.1016/S0968-0896(97)00024-2

Reference yield:

: 75001-09-1
2-(2-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)ethoxy)acetic acid

: 191285-79-7
3-ethyl-5-(2-trimethylsilylethyl)-(+/-)-2-{[2-(2-aminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) carbonyldiimidazole, 2.) pyridine / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, RT, 48 h

2: 4 h / Heating

3: 41 percent / ammonium formate / ethanol / 72 h / 40 °C

4: 71 percent / 40percent aq. methylamine / 5 h / Ambient temperature

With pyridine; ammonium formate; 1,1'-carbonyldiimidazole; methylamine; In ethanol;
DOI:10.1016/S0968-0896(97)00024-2