N-[(R)-2-amino-3-(p-aminophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

Base Information

• Chemical Name: N-[(R)-2-amino-3-(p-aminophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate
• CAS No.: 880644-84-8
• Molecular Formula: C₄₅H₇₆N₄O₁₀
• Molecular Weight: 833.119
• Mol file: 880644-84-8.mol

Synonyms:N-[(R)-2-amino-3-(p-aminophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

Chemical Property of N-[(R)-2-amino-3-(p-aminophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(R)-2-amino-3-(p-aminophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

There total 3 articles about N-[(R)-2-amino-3-(p-aminophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-[(R)-2-amino-3-(p-nitrophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate (880644-82-6) → N-[(R)-2-amino-3-(p-aminophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate (880644-84-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 8h; atmospheric pressure;

DOI:10.1021/jm060317v

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → N-[(R)-2-amino-3-(p-aminophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate (880644-84-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / K₂O₃ / acetonitrile / 72 h

2: 97 percent / H₂ / Pd/C / ethanol / 8 h / atmospheric pressure

With K₂O₃; hydrogen; palladium on activated charcoal; In ethanol; acetonitrile;

DOI:10.1021/jm060317v

Reference yield:

N-[(R)-2-amino-3-(p-nitrophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine trihydrochloride → N-[(R)-2-amino-3-(p-aminophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate (880644-84-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / K₂O₃ / acetonitrile / 72 h

2: 97 percent / H₂ / Pd/C / ethanol / 8 h / atmospheric pressure

With K₂O₃; hydrogen; palladium on activated charcoal; In ethanol; acetonitrile;

DOI:10.1021/jm060317v

upstream raw materials:

N-[(R)-2-amino-3-(p-nitrophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

bromoacetic acid tert-butyl ester

Downstream raw materials:

C₅₅H₈₇N₅O₁₃

N-[(R)-2-amino-3-(p-5-[(2,5-dioxopyrrolidin-1-yl)oxy]-5-oxo-N-phenylpentanamide)-propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

N-[(R)-2-amino-3-(p-aminophenyl-N-{5-oxopentanoic acid})-propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate