N-[(R)-2-amino-3-(p-5-[(2,5-dioxopyrrolidin-1-yl)oxy]-5-oxo-N-phenylpentanamide)-propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

Base Information

Chemical Name:N-[(R)-2-amino-3-(p-5-[(2,5-dioxopyrrolidin-1-yl)oxy]-5-oxo-N-phenylpentanamide)-propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate
CAS No.:880644-86-0
Molecular Formula:C₅₄H₈₅N₅O₁₅
Molecular Weight:1044.29
Hs Code.:

N-[(R)-2-amino-3-(p-5-[(2,5-dioxopyrrolidin-1-yl)oxy]-5-oxo-N-phenylpentanamide)-propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

Synonyms:N-[(R)-2-amino-3-(p-5-[(2,5-dioxopyrrolidin-1-yl)oxy]-5-oxo-N-phenylpentanamide)-propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

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Chemical Property of N-[(R)-2-amino-3-(p-5-[(2,5-dioxopyrrolidin-1-yl)oxy]-5-oxo-N-phenylpentanamide)-propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

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Technology Process of N-[(R)-2-amino-3-(p-5-[(2,5-dioxopyrrolidin-1-yl)oxy]-5-oxo-N-phenylpentanamide)-propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

There total 5 articles about N-[(R)-2-amino-3-(p-5-[(2,5-dioxopyrrolidin-1-yl)oxy]-5-oxo-N-phenylpentanamide)-propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 905825-53-8
N-[(R)-2-amino-3-(p-aminophenyl-N-{5-oxopentanoic acid})-propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 880644-86-0
N-[(R)-2-amino-3-(p-5-[(2,5-dioxopyrrolidin-1-yl)oxy]-5-oxo-N-phenylpentanamide)-propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm060317v

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 880644-86-0
N-[(R)-2-amino-3-(p-5-[(2,5-dioxopyrrolidin-1-yl)oxy]-5-oxo-N-phenylpentanamide)-propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / K₂O₃ / acetonitrile / 72 h

2: 97 percent / H₂ / Pd/C / ethanol / 8 h / atmospheric pressure

3: 71 percent / benzene

4: 84 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / ethyl acetate; dimethylformamide

With K₂O₃; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jm060317v

Reference yield:

: 880644-82-6
N-[(R)-2-amino-3-(p-nitrophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

: 880644-86-0
N-[(R)-2-amino-3-(p-5-[(2,5-dioxopyrrolidin-1-yl)oxy]-5-oxo-N-phenylpentanamide)-propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / H₂ / Pd/C / ethanol / 8 h / atmospheric pressure

2: 71 percent / benzene

3: 84 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / ethyl acetate; dimethylformamide

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm060317v