880644-82-6

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 

Downstream Products

• 880644-84-8 N-[(R)-2-amino-3-(p-aminophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate 
• 157380-45-5 {[(1S,2S)-2-(Bis-carboxymethyl-amino)-cyclohexyl]-[(R)-2-(bis-carboxymethyl-amino)-3-(4-isothiocyanato-phenyl)-propyl]-amino}-acetic acid 
• 1105741-38-5 {[(R)-3-(4-Amino-phenyl)-2-(bis-carboxymethyl-amino)-propyl]-[(1S,2S)-2-(bis-carboxymethyl-amino)-cyclohexyl]-amino}-acetic acid 
• 199480-81-4 {[(1S,2S)-2-(Bis-carboxymethyl-amino)-cyclohexyl]-[(R)-2-(bis-carboxymethyl-amino)-3-(4-nitro-phenyl)-propyl]-amino}-acetic acid 
• 880644-86-0 N-[(R)-2-amino-3-(p-5-[(2,5-dioxopyrrolidin-1-yl)oxy]-5-oxo-N-phenylpentanamide)-propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate 
• 905825-53-8 N-[(R)-2-amino-3-(p-aminophenyl-N-{5-oxopentanoic acid})-propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N'',N''-penta-tert-butyl acetate 

Relevant academic research and scientific papers

Validation of a novel CHX-A″ derivative suitable for peptide conjugation: Small animal PET/CT imaging using yttrium-86-CHX-A″- octreotide

A versatile bifunctional chelating reagent based on a preorganized cyclohexyl derivative of DTPA (CHX-A′) has been developed for the convenient N-terminal labeling of peptides with metal ion radionuclides of Bi(III), In(III), Lu(III), or Y(III). This was

METAL CHELATORS AND METHODS OF THEIR USE

Metal chelators of Formula (I) and Formula (II) are disclosed or a farmaceutically acceptable salt thereof. Also disclosed are metal chelator-targeting moiety complexes, metal chelator-targeting moiety-metal conjugates, kits, and methods of their preparation and use in diagnosis and/or treatment of diseases and conditions, including, inter alia, cancer and thrombosis.

Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p- nitrobenzyl)-trans-CyDTPA

Distinct differences in in vivo stability of the two diastereomeric C- Functionalized CyDTPA chelating agents, (CHX-A DTPA and CHX-B DTPA, both racemates), as recently reported prompted further investigation as to why differences in configuration produced striking effects on the in vivo stability of their yttrium complexes. To this end, the four individual component stereoisomers of CHX-A and CHX-B were synthesized and ability to bind yttrium was investigated both in vitro and in vivo.