N-(2-[7-methoxy-3-(4-methoxy-benzylamino)-naphthalen-1-yl]ethyl)acetamide

Base Information

Chemical Name:N-(2-[7-methoxy-3-(4-methoxy-benzylamino)-naphthalen-1-yl]ethyl)acetamide
CAS No.:1363155-79-6
Molecular Formula:C₂₃H₂₆N₂O₃
Molecular Weight:378.471
Hs Code.:

Synonyms:N-(2-[7-methoxy-3-(4-methoxy-benzylamino)-naphthalen-1-yl]ethyl)acetamide

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Chemical Property of N-(2-[7-methoxy-3-(4-methoxy-benzylamino)-naphthalen-1-yl]ethyl)acetamide

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Technology Process of N-(2-[7-methoxy-3-(4-methoxy-benzylamino)-naphthalen-1-yl]ethyl)acetamide

There total 4 articles about N-(2-[7-methoxy-3-(4-methoxy-benzylamino)-naphthalen-1-yl]ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 686319-38-0
N-[2-(3-bromo-7-methoxy-naphthalen-1-yl)ethyl]acetamide

: 2393-23-9
4-methoxy-benzylamine

: 1363155-79-6
N-(2-[7-methoxy-3-(4-methoxy-benzylamino)-naphthalen-1-yl]ethyl)acetamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 24h; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2012.01.027

Reference yield:

: 139525-77-2
2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride

: 1363155-79-6
N-(2-[7-methoxy-3-(4-methoxy-benzylamino)-naphthalen-1-yl]ethyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / water; ethyl acetate / 20 °C

1.2: 1 h / 0 - 20 °C

2.1: bromine; acetic acid / 6 h / 20 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 24 h / Inert atmosphere; Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; potassium carbonate; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; ethyl acetate; 1.1: Schotten-Baumann reaction / 1.2: Schotten-Baumann reaction;
DOI:10.1016/j.ejmech.2012.01.027

Reference yield:

: 138112-76-2
agomelatine

: 1363155-79-6
N-(2-[7-methoxy-3-(4-methoxy-benzylamino)-naphthalen-1-yl]ethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; acetic acid / 6 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 24 h / Inert atmosphere; Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane;
DOI:10.1016/j.ejmech.2012.01.027