3-(3-(4-bromophenyl)-2-(4-cyano-2-methylphenyl)-1H-pyrrol-1-yl)propanoic acid

Base Information

Chemical Name:3-(3-(4-bromophenyl)-2-(4-cyano-2-methylphenyl)-1H-pyrrol-1-yl)propanoic acid
CAS No.:1208330-49-7
Molecular Formula:C₂₁H₁₇BrN₂O₂
Molecular Weight:409.282
Hs Code.:

Synonyms:3-(3-(4-bromophenyl)-2-(4-cyano-2-methylphenyl)-1H-pyrrol-1-yl)propanoic acid

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Chemical Property of 3-(3-(4-bromophenyl)-2-(4-cyano-2-methylphenyl)-1H-pyrrol-1-yl)propanoic acid

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Technology Process of 3-(3-(4-bromophenyl)-2-(4-cyano-2-methylphenyl)-1H-pyrrol-1-yl)propanoic acid

There total 9 articles about 3-(3-(4-bromophenyl)-2-(4-cyano-2-methylphenyl)-1H-pyrrol-1-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.3%

: 1208331-44-5
4-(2-(4-bromophenyl)-4-oxobutanoyl)-3-methylbenzonitrile

: 107-95-9
3-amino propanoic acid

: 1208330-49-7
3-(3-(4-bromophenyl)-2-(4-cyano-2-methylphenyl)-1H-pyrrol-1-yl)propanoic acid

Guidance literature:: With pyridinium p-toluenesulfonate; In ethanol; at 20 ℃;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 99548-55-7
4-bromo-2-methyl-benzoic acid methyl ester

: 1208330-49-7
3-(3-(4-bromophenyl)-2-(4-cyano-2-methylphenyl)-1H-pyrrol-1-yl)propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide / 8 h / Reflux

2.1: water; sodium hydroxide / ethanol / 12 h / 20 °C

3.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 14 h / 70 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

5.1: brine / dimethyl sulfoxide / 2 h / 165 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

6.2: -78 - 20 °C / Inert atmosphere

7.1: ozone / dichloromethane / 1 h / -78 °C

8.1: pyridinium p-toluenesulfonate / ethanol / 20 °C

With thionyl chloride; water; pyridinium p-toluenesulfonate; ozone; N,N-dimethyl-formamide; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 1208331-40-1
4-(2-(4-bromophenyl)acetyl)-3-methylbenzonitrile

: 1208330-49-7
3-(3-(4-bromophenyl)-2-(4-cyano-2-methylphenyl)-1H-pyrrol-1-yl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: ozone / dichloromethane / 1 h / -78 °C

3.1: pyridinium p-toluenesulfonate / ethanol / 20 °C

With pyridinium p-toluenesulfonate; ozone; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.04.086