5-bromo-2-hydroxy-N'-{(1E)-1-[5-(trifluoromethyl)-1H-indol-2-yl]ethylidene}benzohydrazide

Base Information

Chemical Name:5-bromo-2-hydroxy-N'-{(1E)-1-[5-(trifluoromethyl)-1H-indol-2-yl]ethylidene}benzohydrazide
CAS No.:1373438-75-5
Molecular Formula:C₁₈H₁₃BrF₃N₃O₂
Molecular Weight:440.219
Hs Code.:

Synonyms:5-bromo-2-hydroxy-N'-{(1E)-1-[5-(trifluoromethyl)-1H-indol-2-yl]ethylidene}benzohydrazide

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Chemical Property of 5-bromo-2-hydroxy-N'-{(1E)-1-[5-(trifluoromethyl)-1H-indol-2-yl]ethylidene}benzohydrazide

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Technology Process of 5-bromo-2-hydroxy-N'-{(1E)-1-[5-(trifluoromethyl)-1H-indol-2-yl]ethylidene}benzohydrazide

There total 3 articles about 5-bromo-2-hydroxy-N'-{(1E)-1-[5-(trifluoromethyl)-1H-indol-2-yl]ethylidene}benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1373439-03-2
1-(5-(trifluoromethyl)-1H-indol-2-yl)ethan-1-one

: 39635-10-4
2-hydroxy-5-bromobenzohydrazide

: 1373438-75-5
5-bromo-2-hydroxy-N'-{(1E)-1-[5-(trifluoromethyl)-1H-indol-2-yl]ethylidene}benzohydrazide

Guidance literature:: With acetic acid; In ethanol; Reflux;
DOI:10.1016/j.bmc.2012.10.002

Reference yield: 90.0%

: 1373438-75-5
5-bromo-2-hydroxy-N'-{(1E)-1-[5-(trifluoromethyl)-1H-indol-2-yl]ethylidene}benzohydrazide

Guidance literature:

Reference yield:

: 496946-78-2
5-(trifluoromethyl)-1H-indole-2-carboxylic acid

: 1373438-75-5
5-bromo-2-hydroxy-N'-{(1E)-1-[5-(trifluoromethyl)-1H-indol-2-yl]ethylidene}benzohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 2 h / 0 °C / Reflux

2: acetic acid / ethanol / Reflux

With acetic acid; In diethyl ether; ethanol;
DOI:10.1016/j.bmc.2012.10.002