2-methyl-3-oxopropionic acid butyl ester

Base Information

• Chemical Name: 2-methyl-3-oxopropionic acid butyl ester
• CAS No.: 115992-39-7
• Molecular Formula: C₈H₁₄O₃
• Molecular Weight: 158.197
• Mol file: 115992-39-7.mol

Synonyms:2-methyl-3-oxopropionic acid butyl ester

Chemical Property of 2-methyl-3-oxopropionic acid butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-3-oxopropionic acid butyl ester

There total 2 articles about 2-methyl-3-oxopropionic acid butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + acrylic acid n-butyl ester (141-32-2,9003-49-0) → propionic acid butyl ester (590-01-2) + 4-oxobutyric acid butyl ester (108106-54-3) + 2-methyl-3-oxopropionic acid butyl ester (115992-39-7)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; 1,3-bis-(diphenylphosphino)propane; hydrogen; In water; toluene; at 120 ℃; for 20h; under 7500.75 Torr; regioselective reaction;

DOI:10.1016/j.tetlet.2013.02.049

Reference yield:

acrylic acid n-butyl ester (141-32-2,9003-49-0) + carbon monoxide (201230-82-2) → propionic acid butyl ester (590-01-2) + 4-oxobutyric acid butyl ester (108106-54-3) + 2-methyl-3-oxopropionic acid butyl ester (115992-39-7)

Guidance literature:

With RhH(CO)(P(NC₄H₄)3)3; hydrogen; at 80 ℃; for 1.5h; under 15001.5 Torr; chemoselective reaction; Catalytic behavior; Autoclave;

DOI:10.1039/c9nj04438h

Reference yield: 99.0%

p-toluenesulfonyl chloride (98-59-9) + 2-methyl-3-oxopropionic acid butyl ester (115992-39-7) → butyl (Z)-2-methyl-3-(p-toluenesulfonyloxy)prop-2-enoate (1188274-49-8)

Guidance literature:

With 1-methyl-1H-imidazole; lithium hydroxide; In toluene; at 0 - 5 ℃; optical yield given as %de; Inert atmosphere;

DOI:10.1021/ol9013359

upstream raw materials:

formaldehyd

acrylic acid n-butyl ester

carbon monoxide

Downstream raw materials:

butyl (E)-2-methyl-3-(p-toluenesulfonyloxy)prop-2-enoate

butyl (Z)-2-methyl-3-(p-toluenesulfonyloxy)prop-2-enoate