triisopropyl-[4-(5-isopropyl-6-methoxymethoxy-4'-nitrobiphenyl-3-ylmethyl)-3,5-dimethylphenoxy]silane

Base Information

• Chemical Name: triisopropyl-[4-(5-isopropyl-6-methoxymethoxy-4'-nitrobiphenyl-3-ylmethyl)-3,5-dimethylphenoxy]silane
• CAS No.: 417871-28-4
• Molecular Formula: C₃₅H₄₉NO₅Si
• Molecular Weight: 591.863
• Mol file: 417871-28-4.mol

Synonyms:triisopropyl-[4-(5-isopropyl-6-methoxymethoxy-4'-nitrobiphenyl-3-ylmethyl)-3,5-dimethylphenoxy]silane

Chemical Property of triisopropyl-[4-(5-isopropyl-6-methoxymethoxy-4'-nitrobiphenyl-3-ylmethyl)-3,5-dimethylphenoxy]silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of triisopropyl-[4-(5-isopropyl-6-methoxymethoxy-4'-nitrobiphenyl-3-ylmethyl)-3,5-dimethylphenoxy]silane

There total 2 articles about triisopropyl-[4-(5-isopropyl-6-methoxymethoxy-4'-nitrobiphenyl-3-ylmethyl)-3,5-dimethylphenoxy]silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

p-nitrobenzene iodide (636-98-6) + {5'-[2,6-dimethyl-4-(triisopropylsilanyloxy)benzyl]-3-isopropyl-2-methoxymethoxyphenyl}boronic acid (417871-20-6) → triisopropyl-[4-(5-isopropyl-6-methoxymethoxy-4'-nitrobiphenyl-3-ylmethyl)-3,5-dimethylphenoxy]silane (417871-28-4)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium carbonate; In ethanol; toluene; for 8h; Heating;

DOI:10.1016/S0968-0896(01)00284-X

Reference yield:

3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)-O-triisopropylsilylphenol (328236-46-0) → triisopropyl-[4-(5-isopropyl-6-methoxymethoxy-4'-nitrobiphenyl-3-ylmethyl)-3,5-dimethylphenoxy]silane (417871-28-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 2 h / 20 °C

1.2: tetrahydrofuran; hexane / 1 h / 20 °C

2.1: 68 percent / Pd₂(dba)3*CHCl₃; Cs₂CO₃ / toluene; ethanol / 8 h / Heating

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; n-butyllithium; caesium carbonate; In tetrahydrofuran; ethanol; hexane; toluene; 2.1: Suzuki coupling;

DOI:10.1016/S0968-0896(01)00284-X

Reference yield: 95.0%

triisopropyl-[4-(5-isopropyl-6-methoxymethoxy-4'-nitrobiphenyl-3-ylmethyl)-3,5-dimethylphenoxy]silane (417871-28-4) → 4-(5-isopropyl-6-methoxymethoxy-4'-nitrobiphenyl-3-ylmethyl)-3,5-dimethylphenol (417871-51-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1016/S0968-0896(01)00284-X

upstream raw materials:

p-nitrobenzene iodide

{5'-[2,6-dimethyl-4-(triisopropylsilanyloxy)benzyl]-3-isopropyl-2-methoxymethoxyphenyl}boronic acid

3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)-O-triisopropylsilylphenol

Downstream raw materials:

4-(5-isopropyl-6-methoxymethoxy-4'-nitrobiphenyl-3-ylmethyl)-3,5-dimethylphenol

5'-[2,6-dimethyl-4-(triisopropylsilanyloxy)benzyl]-3'-isopropyl-2'-methoxymethoxybiphenyl-4-ylamine

4-(4'-amino-5-isopropyl-6-methoxymethoxybiphenyl-3-ylmethyl)-3,5-dimethylphenol

[4-(4'-amino-5-isopropyl-6-methoxymethoxybiphenyl-3-ylmethyl)-3,5-dimethylphenoxy]acetic acid ethyl ester