[2-[(3-methylphenyl)carbamothioylcarbamoyl]phenyl] acetate

Base Information

• Chemical Name: [2-[(3-methylphenyl)carbamothioylcarbamoyl]phenyl] acetate
• CAS No.: 1232634-20-6
• Molecular Formula: C₁₇H₁₆N₂O₃S
• Molecular Weight: 328.392
• Mol file: 1232634-20-6.mol

Synonyms:[2-[(3-methylphenyl)carbamothioylcarbamoyl]phenyl] acetate

Chemical Property of [2-[(3-methylphenyl)carbamothioylcarbamoyl]phenyl] acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of [2-[(3-methylphenyl)carbamothioylcarbamoyl]phenyl] acetate

There total 4 articles about [2-[(3-methylphenyl)carbamothioylcarbamoyl]phenyl] acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.48%

acetoxybenzoyl isothiocyanate (1232634-50-2) + 1-amino-3-methylbenzene (108-44-1) → [2-[(3-methylphenyl)carbamothioylcarbamoyl]phenyl] acetate (1232634-20-6)

Guidance literature:

In Dimethyl ether; at 20 ℃; for 1h; Reflux;

DOI:10.2174/15701808113106660075

Reference yield:

O-acetylsalicyloyl chloride (5538-51-2) → [2-[(3-methylphenyl)carbamothioylcarbamoyl]phenyl] acetate (1232634-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: PEG-400 / 1 h / 20 °C

2: Dimethyl ether / 1 h / 20 °C / Reflux

With PEG-400; In Dimethyl ether;

DOI:10.2174/15701808113106660075

Reference yield:

aspirin (50-78-2,98201-60-6) → [2-[(3-methylphenyl)carbamothioylcarbamoyl]phenyl] acetate (1232634-20-6)

Guidance literature:

Multi-step reaction with 3 steps

1: bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; Dimethyl ether / 2 h / Reflux

2: PEG-400 / 1 h / 20 °C

3: Dimethyl ether / 1 h / 20 °C / Reflux

With bis(trichloromethyl) carbonate; In Dimethyl ether; N,N-dimethyl-formamide;

DOI:10.2174/15701808113106660075

upstream raw materials:

salicylic acid

aspirin

O-acetylsalicyloyl chloride

acetoxybenzoyl isothiocyanate