Ethyl 3-[2-(2-bromo-5-methoxyphenyl)ethyl]-2-methyl-4-oxocyclohex-2-enecarboxylate

Base Information

Chemical Name:Ethyl 3-[2-(2-bromo-5-methoxyphenyl)ethyl]-2-methyl-4-oxocyclohex-2-enecarboxylate
CAS No.:198630-97-6
Molecular Formula:C₁₉H₂₃BrO₄
Molecular Weight:395.293
Hs Code.:

Synonyms:Ethyl 3-[2-(2-bromo-5-methoxyphenyl)ethyl]-2-methyl-4-oxocyclohex-2-enecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 3-[2-(2-bromo-5-methoxyphenyl)ethyl]-2-methyl-4-oxocyclohex-2-enecarboxylate

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Technology Process of Ethyl 3-[2-(2-bromo-5-methoxyphenyl)ethyl]-2-methyl-4-oxocyclohex-2-enecarboxylate

There total 7 articles about Ethyl 3-[2-(2-bromo-5-methoxyphenyl)ethyl]-2-methyl-4-oxocyclohex-2-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 487-51-4
4-carbethoxy-3-methyl-2-cyclohexen-1-one

: 198630-95-4
2-(2-Bromo-5-methoxyphenyl)ethyl bromide

: 198630-97-6
Ethyl 3-[2-(2-bromo-5-methoxyphenyl)ethyl]-2-methyl-4-oxocyclohex-2-enecarboxylate

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol;

Reference yield:

: 27060-75-9
4-bromo-3-methylanisole

: 198630-97-6
Ethyl 3-[2-(2-bromo-5-methoxyphenyl)ethyl]-2-methyl-4-oxocyclohex-2-enecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 69 percent / Br₂, (PhCO₂)2 / CCl₄ / 1 h / Heating

2: dimethylsulfoxide / 0.75 h / Ambient temperature

3: aq. KOH / ethanol / 14 h / Heating

4: conc. H₂SO₄ / 7 h / Heating

5: 93 percent / LiAlH₄ / diethyl ether / 2 h / 25 - 30 °C

6: PBr₃ / benzene / 1.) r.t., overnight, 2.) 70-80 deg C, 2 h

7: 62 percent / t-BuOK / 2-methyl-propan-2-ol

With potassium hydroxide; lithium aluminium tetrahydride; sulfuric acid; potassium tert-butylate; bromine; phosphorus tribromide; dibenzoyl peroxide; In tetrachloromethane; diethyl ether; ethanol; dimethyl sulfoxide; tert-butyl alcohol; benzene;

Reference yield:

: 19614-12-1
2-bromo-5-methoxybenzyl bromide

: 198630-97-6
Ethyl 3-[2-(2-bromo-5-methoxyphenyl)ethyl]-2-methyl-4-oxocyclohex-2-enecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: dimethylsulfoxide / 0.75 h / Ambient temperature

2: aq. KOH / ethanol / 14 h / Heating

3: conc. H₂SO₄ / 7 h / Heating

4: 93 percent / LiAlH₄ / diethyl ether / 2 h / 25 - 30 °C

5: PBr₃ / benzene / 1.) r.t., overnight, 2.) 70-80 deg C, 2 h

6: 62 percent / t-BuOK / 2-methyl-propan-2-ol

With potassium hydroxide; lithium aluminium tetrahydride; sulfuric acid; potassium tert-butylate; phosphorus tribromide; In diethyl ether; ethanol; dimethyl sulfoxide; tert-butyl alcohol; benzene;