1-[4-(4-dimethylaminophenylazo)-3-iodo-phenyl]-2,2,2-trifluoroethanone

Base Information

• Chemical Name: 1-[4-(4-dimethylaminophenylazo)-3-iodo-phenyl]-2,2,2-trifluoroethanone
• CAS No.: 514225-86-6
• Molecular Formula: C₁₆H₁₃F₃IN₃O
• Molecular Weight: 447.198
• Mol file: 514225-86-6.mol

Synonyms:1-[4-(4-dimethylaminophenylazo)-3-iodo-phenyl]-2,2,2-trifluoroethanone

Chemical Property of 1-[4-(4-dimethylaminophenylazo)-3-iodo-phenyl]-2,2,2-trifluoroethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-(4-dimethylaminophenylazo)-3-iodo-phenyl]-2,2,2-trifluoroethanone

There total 2 articles about 1-[4-(4-dimethylaminophenylazo)-3-iodo-phenyl]-2,2,2-trifluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

4-amino-N,N-dimethylaniline (99-98-9) + 1-(4-amino-3-iodophenyl)-2,2,2-trifluoroethanone (812640-39-4) → 1-[4-(4-dimethylaminophenylazo)-3-iodo-phenyl]-2,2,2-trifluoroethanone (514225-86-6)

Guidance literature:

1-(4-amino-3-iodophenyl)-2,2,2-trifluoroethanone; With hydrogenchloride; sodium nitrite; at 0 ℃;

4-amino-N,N-dimethylaniline; In ethanol; water; at 0 - 20 ℃;

DOI:10.1016/j.tet.2004.08.100

Reference yield:

4-(trifluoroacetyl)aniline (23516-79-2) → 1-[4-(4-dimethylaminophenylazo)-3-iodo-phenyl]-2,2,2-trifluoroethanone (514225-86-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 62 percent / iodine monochloride; aq. HCl / H₂O / 12 h / 20 °C

2.1: aq. HCl; sodium nitrite / 0 °C

2.2: 44 percent / ethanol; H₂O / 0 - 20 °C

With hydrogenchloride; Iodine monochloride; sodium nitrite; In water;

DOI:10.1016/j.tet.2004.08.100

Reference yield: 89.0%

1-[4-(4-dimethylaminophenylazo)-3-iodo-phenyl]-2,2,2-trifluoroethanone (514225-86-6) + 2,4,6-tris-[3,5-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-cyclotriboroxane → 1-[4-(4-dimethylaminophenylazo)-3-(3,5-bis(tert-butyldimethylsilyloxy)phenyl)phenyl]-2,2,2-trifluoroethanone (514225-87-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; benzene; at 50 - 55 ℃; for 5h;

DOI:10.1016/j.tet.2004.08.100

upstream raw materials:

4-amino-N,N-dimethylaniline

1-(4-amino-3-iodophenyl)-2,2,2-trifluoroethanone

4-(trifluoroacetyl)aniline

Downstream raw materials:

1-[4-(4-dimethylaminophenylazo)-3-(3,5-bis(tert-butyldimethylsilyloxy)phenyl)phenyl]-2,2,2-trifluoroethanone