N-(3,5-DINITROBENZOYL)-DL-LEUCINE

Base Information

• Chemical Name: N-(3,5-DINITROBENZOYL)-DL-LEUCINE
• CAS No.: 74928-54-4
• Molecular Formula: C13H15 N3 O7
• Molecular Weight: 325.278
• Hs Code.: 2924299090
• Mol file: 74928-54-4.mol

Synonyms:DL-Leucine,N-(3,5-dinitrobenzoyl)-; (RS)-3,5-Dinitrobenzoylleucine;N-(3,5-Dinitrobenzoyl)-DL-leucine

Chemical Property of N-(3,5-DINITROBENZOYL)-DL-LEUCINE

Chemical Property:

• Vapor Pressure: 1.84E-11mmHg at 25°C
• Melting Point: 200-202 °C(lit.)
• Refractive Index: 1.585
• Boiling Point: 515.7°C at 760 mmHg
• PKA: 3.77±0.40(Predicted)
• Flash Point: 265.7°C
• PSA: 158.04000
• Density: 1.405g/cm³
• LogP: 3.16940
• Storage Temp.: -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(3,5-Dinitrobenzoyl)-DL-leucine 99% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3,5-DINITROBENZOYL)-DL-LEUCINE

There total 2 articles about N-(3,5-DINITROBENZOYL)-DL-LEUCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

LEUCINE (328-39-2,21675-61-6,25248-98-0,70-45-1) + 3,5-dinitrobenoyl chloride (99-33-2) → 3,5-(NO2)2C6H3CONHCH(CH2CH(CH3)2)COOH (74928-54-4)

Guidance literature:

With methyloxirane; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.0c00027

Reference yield:

4-isobutylidene-2-thioxo-thiazolidin-5-one → 3,5-(NO2)2C6H3CONHCH(CH2CH(CH3)2)COOH (74928-54-4)

Guidance literature:

Multi-step reaction with 2 steps

1: glacial acetic acid; aqueous HI; phosphorus

2: aq. NaOH solution

With phosphorus; sodium hydroxide; hydrogen iodide; acetic acid;

DOI:10.1039/jr9490002323

Reference yield: 77.0%

3,5-(NO2)2C6H3CONHCH(CH2CH(CH3)2)COOH (74928-54-4) + dimethyl amine (124-40-3) → (R,S)-N-(3,5-dinitrobenzoyl)leucine dimethylamide

Guidance literature:

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In tetrahydrofuran; for 4h;

DOI:10.1021/jo951255b

upstream raw materials:

LEUCINE

3,5-dinitrobenoyl chloride

Downstream raw materials:

(S)-N-(3,5-dinitrobenzoyl)leucine

N-(3,5-dinitrobenzoyl)-(R)-leucine

N-(3,5-dinitrobenzoyl)-L-leucine methyl ester