(S)-N-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

Base Information

Chemical Name:(S)-N-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide
CAS No.:1240522-08-0
Molecular Formula:C₂₂H₂₂N₆OS
Molecular Weight:418.522
Hs Code.:

Synonyms:(S)-N-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

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Chemical Property of (S)-N-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

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Technology Process of (S)-N-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

There total 6 articles about (S)-N-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 3364-80-5
1,3-thiazole-4-carbaldehyde

: 1240522-05-7
(S)-tert-butyl 1-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxo-3-phenylpropan-2-ylcarbamate

: 1240522-08-0
(S)-N-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

Guidance literature:: 1,3-thiazole-4-carbaldehyde; (S)-tert-butyl 1-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxo-3-phenylpropan-2-ylcarbamate; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 60 ℃; for 0.583333h;

With water; sodium hydrogencarbonate; In 1,2-dichloro-ethane;

Reference yield:

: 23821-37-6
3-oxo-3-(pyridin-4-yl)propanenitrile

: 1240522-08-0
(S)-N-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 2.5 h / 60 °C

2: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 2 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

4: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 0.58 h / 60 °C

With pyridine; sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In methanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 38965-47-8
1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-amine

: 1240522-08-0
(S)-N-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 2 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

3: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 0.58 h / 60 °C

With pyridine; sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;