8-((3R,4S)-4-methylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

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Chemical Name:8-((3R,4S)-4-methylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine
CAS No.:1428243-43-9
Molecular Formula:C₂₀H₂₁N₅O₂S
Molecular Weight:395.485
Hs Code.:

Synonyms:8-((3R,4S)-4-methylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

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Chemical Property of 8-((3R,4S)-4-methylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

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Technology Process of 8-((3R,4S)-4-methylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

There total 11 articles about 8-((3R,4S)-4-methylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1428243-42-8
(3S,4R)-benzyl 3-methyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidine-1-carboxylate

: 1428243-43-9
8-((3R,4S)-4-methylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

Guidance literature:: With hydrogen bromide; In acetic acid; at 20 ℃; for 2h;

Reference yield:

: 261896-27-9
(cis)-ethyl 1-benzyl-4-methylpyrrolidine-3-carboxylate

: 1428243-43-9
8-((3R,4S)-4-methylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

Guidance literature:: Multi-step reaction with 10 steps

1.1: water; hydrogenchloride / 15 h / Reflux

2.1: sodium hydroxide; hydrogen; hydrogenchloride; 20% palladium hydroxide on charcoal / water / 16 h / 50 °C / 1551.49 Torr / pH Ca. 2.5

3.1: sodium hydroxide / water / pH Ca_. 11

3.2: 6 h / pH Ca_. 10 - Ca_. 12

3.3: pH Ca_. 2 - Ca_. 3

4.1: acetonitrile / 16 h

5.1: hydrogenchloride / water; diethyl ether

5.2: 3 h

6.1: tetrahydrofuran; acetonitrile / 2 h / 0 - 10 °C

6.2: 1.5 h / 10 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h

7.2: 2 h / 0 - 20 °C

8.1: trifluoroacetic acid / dichloromethane / 48 h / 20 °C / Inert atmosphere

9.1: Lawessons reagent / 1,4-dioxane / 15 h / 70 °C / Inert atmosphere

9.2: 15 h / 20 °C

9.3: 1 h / Saturated solution

10.1: hydrogen bromide / acetic acid / 2 h / 20 °C

With Lawessons reagent; hydrogenchloride; 20% palladium hydroxide on charcoal; water; hydrogen bromide; hydrogen; sodium hydride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1201187-44-1
N-(5-(p-toluenesulfonyl)pyrrolo[2,3-b]pyrazin-2-yl)carbamic acid tert-butyl ester

: 1428243-43-9
8-((3R,4S)-4-methylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h

1.2: 2 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 48 h / 20 °C / Inert atmosphere

3.1: Lawessons reagent / 1,4-dioxane / 15 h / 70 °C / Inert atmosphere

3.2: 15 h / 20 °C

3.3: 1 h / Saturated solution

4.1: hydrogen bromide / acetic acid / 2 h / 20 °C

With Lawessons reagent; hydrogen bromide; sodium hydride; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; acetic acid; N,N-dimethyl-formamide; mineral oil;