benzyl 4-<((benzyloxy)carbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate

Base Information

• Chemical Name: benzyl 4-<((benzyloxy)carbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate
• CAS No.: 99018-00-5
• Molecular Formula: C₂₃H₂₃NO₄
• Molecular Weight: 377.44
• Mol file: 99018-00-5.mol

Synonyms:benzyl 4-<((benzyloxy)carbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate

Chemical Property of benzyl 4-<((benzyloxy)carbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of benzyl 4-<((benzyloxy)carbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate

There total 2 articles about benzyl 4-<((benzyloxy)carbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.2%

ethyl 4<(methoxycarbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate (99017-93-3) + benzyl alcohol (100-51-6,185532-71-2) → benzyl 4-<((benzyloxy)carbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate (99018-00-5)

Guidance literature:

With sodium phenyl-methanolate; Heating;

DOI:10.1021/jo00350a033

Reference yield:

acetylacetone (123-54-6,81235-32-7) → benzyl 4-<((benzyloxy)carbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate (99018-00-5)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃, KI / butan-2-one / Heating

2: 75 percent / AcOH / Heating

3: 86.2 percent / BnONa / Heating

With potassium carbonate; acetic acid; sodium phenyl-methanolate; potassium iodide; In butanone;

DOI:10.1021/jo00350a033

Reference yield: 96.3%

methanol (67-56-1) + benzyl 4-<((benzyloxy)carbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate (99018-00-5) → benzyl 4-<(methoxycarbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate (31837-62-4)

Guidance literature:

With sodium methylate; In tetrahydrofuran; for 0.333333h; Ambient temperature;

DOI:10.1021/jo00350a033

upstream raw materials:

ethyl 4<(methoxycarbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate

benzyl alcohol

acetylacetone

Downstream raw materials:

benzyl 4-<(methoxycarbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate