5-Cyano-4-(1H-indol-3-yl)-2-phenyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 5-Cyano-4-(1H-indol-3-yl)-2-phenyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester
• CAS No.: 211936-51-5
• Molecular Formula: C₂₃H₁₇N₃O₂S
• Molecular Weight: 399.473

Synonyms:5-Cyano-4-(1H-indol-3-yl)-2-phenyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester

Chemical Property of 5-Cyano-4-(1H-indol-3-yl)-2-phenyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 5-Cyano-4-(1H-indol-3-yl)-2-phenyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester

There total 1 articles about 5-Cyano-4-(1H-indol-3-yl)-2-phenyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethyl 3-oxo-3-phenylpropionate (94-02-0) + 2-cyano-3-(1H-indol-3-yl)prop-2-enethioamide → 5-Cyano-4-(1H-indol-3-yl)-2-phenyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester (211936-51-5)

Guidance literature:

With pyridine; triethylamine; In ethanol; for 6h; Heating;

DOI:10.1080/10426509708043543

Reference yield: 85.0%

chloroacetic acid ethyl ester (105-39-5) + 5-Cyano-4-(1H-indol-3-yl)-2-phenyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester (211936-51-5) → 5-Cyano-6-ethoxycarbonylmethylsulfanyl-4-(1H-indol-3-yl)-2-phenyl-nicotinic acid ethyl ester (211936-60-6)

Guidance literature:

With sodium methylate; In methanol; Heating;

DOI:10.1080/10426509708043543

Reference yield: 85.0%

α-bromoacetophenone (70-11-1) + 5-Cyano-4-(1H-indol-3-yl)-2-phenyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester (211936-51-5) → 3-Amino-2-benzoyl-4-(1H-indol-3-yl)-6-phenyl-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester

Guidance literature:

With sodium methylate; In methanol; Heating;

DOI:10.1080/10426509708043543

upstream raw materials:

ethyl 3-oxo-3-phenylpropionate

Downstream raw materials:

5-Cyano-6-ethoxycarbonylmethylsulfanyl-4-(1H-indol-3-yl)-2-phenyl-nicotinic acid ethyl ester

5-Cyano-4-(1H-indol-3-yl)-6-(2-oxo-propylsulfanyl)-2-phenyl-nicotinic acid ethyl ester

6-(1-Acetyl-2-oxo-propylsulfanyl)-5-cyano-4-(1H-indol-3-yl)-2-phenyl-nicotinic acid ethyl ester

5-Cyano-6-(1-ethoxycarbonyl-2-oxo-propylsulfanyl)-4-(1H-indol-3-yl)-2-phenyl-nicotinic acid ethyl ester

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