γ-morpholinobutenolide

Base Information

• Chemical Name: γ-morpholinobutenolide
• CAS No.: 78920-07-7
• Molecular Formula: C₉H₁₃NO₃
• Molecular Weight: 183.207
• Mol file: 78920-07-7.mol

Synonyms:γ-morpholinobutenolide

Chemical Property of γ-morpholinobutenolide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of γ-morpholinobutenolide

There total 1 articles about γ-morpholinobutenolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl glyoxylate methyl hemi-acetal (109745-70-2,19757-97-2) + (E)-1-(N-morpholino)propene (51043-49-3) → methyl (E)-3-formylcrotonate (40835-18-5) + γ-morpholinobutenolide (78920-07-7)

Guidance literature:

With water; toluene-4-sulfonic acid; Yield given. Multistep reaction; 1.) benzene, reflux, 1.5 h, 2.) ether, 20 deg C, 1 h;

DOI:10.1021/jo00230a026

Reference yield:

γ-morpholinobutenolide (78920-07-7) → 5-hydroxy-4-methyl-5H-furan-2-one (40834-42-2)

Guidance literature:

With hydrogenchloride; for 0.25h; Yield given; Heating;

DOI:10.1021/jo00337a013

Reference yield:

γ-morpholinobutenolide (78920-07-7) → 5-methylpyridazin-3(2H)-one (54709-94-3)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. HCl / 0.25 h / Heating

2: HCl(g) / 12 h / Heating

3: 60 percent / H₂N-NH₂*H₂O / aq. ethanol / 3 h / Heating

With hydrogenchloride; hydrazine hydrate; In ethanol;

DOI:10.1021/jo00337a013

upstream raw materials:

methyl glyoxylate methyl hemi-acetal

(E)-1-(N-morpholino)propene

Downstream raw materials:

5-hydroxy-4-methyl-5H-furan-2-one

5-methylpyridazin-3(2H)-one

Refernces