Technology Process of Benzene, 1-bromo-2-ethyl-3-nitro- (9CI)
There total 4 articles about Benzene, 1-bromo-2-ethyl-3-nitro- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-ethyl-3-nitrobenzeneamine;
With
hydrogen bromide; sodium nitrite;
In
water;
at 0 ℃;
for 0.166667h;
With
urea;
In
water;
for 0.0833333h;
With
hydrogen bromide; copper; copper(II) sulfate;
In
water;
at 80 ℃;
for 1h;
DOI:10.1002/hlca.200490060
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 81 percent / formic acid; Et3N / Pd/C / acetonitrile / 0.42 h / Heating
2.1: aq. HBr; NaNO2 / H2O / 0.17 h / 0 °C
2.2: urea / H2O / 0.08 h
2.3: 87 percent / CuSO4*5H2O; Cu; aq. HBr / H2O / 1 h / 80 °C
With
formic acid; hydrogen bromide; triethylamine; sodium nitrite;
palladium on activated charcoal;
In
water; acetonitrile;
DOI:10.1002/hlca.200490060
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 48 percent / ammonia; H2S / dioxane / 35 - 40 °C
2.1: NaNO2; AcOH; H2SO4 / H2O / 1 h / 20 - 25 °C
2.2: 76 percent / Cu2O / ethanol; H2O / 1.5 h / 20 °C
3.1: 81 percent / formic acid; Et3N / Pd/C / acetonitrile / 0.42 h / Heating
4.1: aq. HBr; NaNO2 / H2O / 0.17 h / 0 °C
4.2: urea / H2O / 0.08 h
4.3: 87 percent / CuSO4*5H2O; Cu; aq. HBr / H2O / 1 h / 80 °C
With
formic acid; sulfuric acid; hydrogen sulfide; ammonia; hydrogen bromide; acetic acid; triethylamine; sodium nitrite;
palladium on activated charcoal;
In
1,4-dioxane; water; acetonitrile;
DOI:10.1002/hlca.200490060
