1-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)-3-phenyl thiourea

Base Information

Chemical Name:1-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)-3-phenyl thiourea
CAS No.:1418149-88-8
Molecular Formula:C₂₇H₂₅N₉OS₂
Molecular Weight:555.687
Hs Code.:

Synonyms:1-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)-3-phenyl thiourea

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Chemical Property of 1-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)-3-phenyl thiourea

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Technology Process of 1-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)-3-phenyl thiourea

There total 11 articles about 1-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)-3-phenyl thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.6%

: 1418149-58-2
7-(4-methylpiperazin-1-yl)-4-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)sulfanyl]quinazolin-6-amine

: 103-72-0
phenyl isothiocyanate

: 1418149-88-8
1-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)-3-phenyl thiourea

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1007/s00044-012-0408-0

Reference yield:

: 53449-14-2
7-chloro-6-nitro-4(3H)-quinazolinone

: 1418149-88-8
1-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)-3-phenyl thiourea

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus pentachloride / 3 h / 160 °C

2.1: potassium carbonate / isopropyl alcohol / 7 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / Reflux

3.2: 5 h / Reflux

4.1: acetic acid; iron / water / 5 h / 10 - 20 °C

5.1: N,N-dimethyl-formamide / 12 h / 20 °C

With phosphorus pentachloride; iron; potassium carbonate; acetic acid; In water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1007/s00044-012-0408-0

Reference yield:

: 59-67-6
nicotinic acid

: 1418149-88-8
1-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)-3-phenyl thiourea

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 4 h / 20 °C / Reflux

2.1: hydrazine hydrate / ethanol / Reflux

3.1: potassium hydroxide / ethanol / 5 h / Reflux

4.1: potassium carbonate / isopropyl alcohol / 7 h / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / Reflux

5.2: 5 h / Reflux

6.1: acetic acid; iron / water / 5 h / 10 - 20 °C

7.1: N,N-dimethyl-formamide / 12 h / 20 °C

With potassium hydroxide; sulfuric acid; iron; potassium carbonate; hydrazine hydrate; acetic acid; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1007/s00044-012-0408-0