ethyl ester of N-(3-hydroxypropyl)-α-phenylglycine

Base Information

• Chemical Name: ethyl ester of N-(3-hydroxypropyl)-α-phenylglycine
• CAS No.: 302588-88-1
• Molecular Formula: C₁₃H₁₉NO₃
• Molecular Weight: 237.299
• Mol file: 302588-88-1.mol

Synonyms:ethyl ester of N-(3-hydroxypropyl)-α-phenylglycine

Chemical Property of ethyl ester of N-(3-hydroxypropyl)-α-phenylglycine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl ester of N-(3-hydroxypropyl)-α-phenylglycine

There total 1 articles about ethyl ester of N-(3-hydroxypropyl)-α-phenylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 2-phenyl-2-bromoacetate (2882-19-1,2216-90-2) + propan-1-ol-3-amine (156-87-6) → ethyl ester of N-(3-hydroxypropyl)-α-phenylglycine (302588-88-1)

Guidance literature:

With potassium carbonate; In chloroform; at 40 - 45 ℃; for 2h;

DOI:10.1007/BF02269538

Reference yield: 89.0%

ethyl ester of N-(3-hydroxypropyl)-α-phenylglycine (302588-88-1) → hydrochloride of the ethyl ester of N-(3-chloropropyl)-α-phenylglycine

Guidance literature:

With thionyl chloride; In chloroform; at 50 ℃; for 3h;

DOI:10.1007/BF02269538

Reference yield:

ethyl ester of N-(3-hydroxypropyl)-α-phenylglycine (302588-88-1) → 1-acetyl-2-phenylproline (308841-65-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 89 percent / SOCl₂ / CHCl₃ / 3 h / 50 °C

2: 94 percent / NaOAc / 4 h

3: 96 percent / triethylbenzylammonium chloride; K₂CO₃ / acetonitrile / 4 h / 45 - 50 °C

4: 80 percent / NaOH / methanol / 4 h / Heating

With sodium hydroxide; thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; sodium acetate; potassium carbonate; In methanol; chloroform; acetonitrile; 1: Substitution / 2: Acetylation / 3: Cyclization / 4: Hydrolysis;

DOI:10.1007/BF02269538

upstream raw materials:

ethyl 2-phenyl-2-bromoacetate

propan-1-ol-3-amine

Downstream raw materials:

1-acetyl-2-phenylproline

ethyl ester of 1-acetyl-2-phenylproline

ethyl ester of N-acetyl-N-(3-chloropropyl)-α-phenylglycine