[4bS-(4bα,7α,8aβ)]-4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-4b-(phenylmethyl)-7-(1-propynyl)-2-phenanthrenecarboxylic acid methyl ester

Base Information

Chemical Name:[4bS-(4bα,7α,8aβ)]-4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-4b-(phenylmethyl)-7-(1-propynyl)-2-phenanthrenecarboxylic acid methyl ester
CAS No.:305822-71-3
Molecular Formula:C₂₆H₂₈O₃
Molecular Weight:388.507
Hs Code.:

Synonyms:[4bS-(4bα,7α,8aβ)]-4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-4b-(phenylmethyl)-7-(1-propynyl)-2-phenanthrenecarboxylic acid methyl ester

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Chemical Property of [4bS-(4bα,7α,8aβ)]-4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-4b-(phenylmethyl)-7-(1-propynyl)-2-phenanthrenecarboxylic acid methyl ester

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Technology Process of [4bS-(4bα,7α,8aβ)]-4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-4b-(phenylmethyl)-7-(1-propynyl)-2-phenanthrenecarboxylic acid methyl ester

There total 9 articles about [4bS-(4bα,7α,8aβ)]-4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-4b-(phenylmethyl)-7-(1-propynyl)-2-phenanthrenecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: trifluoromethanesulfonic acid [4bS-(4bα,7α,8aβ)]-4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-4b-(phenylmethyl)-7-(1-propynyl)-2-phenanthrenyl ester

: 305822-71-3
[4bS-(4bα,7α,8aβ)]-4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-4b-(phenylmethyl)-7-(1-propynyl)-2-phenanthrenecarboxylic acid methyl ester

Guidance literature:: With 1,3-bis(diphenylphosphino)propanol; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 4h; under 3102.97 Torr;

Reference yield:

: 1-benzyl-6-methoxy-1-(3-oxo-butyl)-3,4-dihydro-1H-naphthalen-2-one

: 305822-71-3
[4bS-(4bα,7α,8aβ)]-4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-4b-(phenylmethyl)-7-(1-propynyl)-2-phenanthrenecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / methanol / 3.25 h / 20 - 75 °C

2.1: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane / 1.5 h / -78 - 20 °C / Inert atmosphere

3.1: ammonia; lithium / 1,4-dioxane; diethyl ether / 0.5 h / -78 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

4.2: 20 °C

5.1: 2,6-dimethylpyridine; dmap / dichloromethane / 2.5 h / -40 - 20 °C / Inert atmosphere

6.1: 1,3-bis(diphenylphosphino)propanol; triethylamine; palladium diacetate / N,N-dimethyl-formamide / 4 h / 70 °C / 3102.97 Torr

With 2,6-dimethylpyridine; dmap; 1,3-bis(diphenylphosphino)propanol; ammonia; sodium methylate; palladium diacetate; boron trichloride; tetra-(n-butyl)ammonium iodide; lithium; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 305822-65-5
CP-409069

: 305822-71-3
[4bS-(4bα,7α,8aβ)]-4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-4b-(phenylmethyl)-7-(1-propynyl)-2-phenanthrenecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine; dmap / dichloromethane / 2.5 h / -40 - 20 °C / Inert atmosphere

2: 1,3-bis(diphenylphosphino)propanol; triethylamine; palladium diacetate / N,N-dimethyl-formamide / 4 h / 70 °C / 3102.97 Torr

With 2,6-dimethylpyridine; dmap; 1,3-bis(diphenylphosphino)propanol; palladium diacetate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;