methyl 4-<3-(chloroacetamido) 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxamido>benzoate

Base Information

Chemical Name:methyl 4-<3-(chloroacetamido) 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxamido>benzoate
CAS No.:155877-92-2
Molecular Formula:C₂₅H₂₉ClN₂O₄
Molecular Weight:456.969
Hs Code.:

Synonyms:methyl 4-<3-(chloroacetamido) 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxamido>benzoate

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Chemical Property of methyl 4-<3-(chloroacetamido) 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxamido>benzoate

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Technology Process of methyl 4-<3-(chloroacetamido) 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxamido>benzoate

There total 5 articles about methyl 4-<3-(chloroacetamido) 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxamido>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 79-04-9
chloroacetyl chloride

: 155877-90-0
methyl 4-<(3-amino)-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxamido>benzoate

: 155877-92-2
methyl 4-<3-(chloroacetamido) 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxamido>benzoate

Guidance literature:: With pyridine; In diethyl ether; for 5h; Ambient temperature;
DOI:10.1021/jm00036a017

Reference yield:

: 103031-30-7
5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxylic acid

: 155877-92-2
methyl 4-<3-(chloroacetamido) 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxamido>benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / HNO₃, H₂SO₄ / 1 h / Ambient temperature

2: thionyl chloride / 2 h / 55 °C

3: pyridine / diethyl ether

4: 74 percent / Fe, aq. NH₄Cl / methanol / 3.5 h / Heating

5: 70 percent / pyridine / diethyl ether / 5 h / Ambient temperature

With pyridine; thionyl chloride; sulfuric acid; nitric acid; iron; ammonium chloride; In methanol; diethyl ether;
DOI:10.1021/jm00036a017

Reference yield:

: 5,5,8,8-Tetramethyl-3-nitro-5,6,7,8-tetrahydro-naphthalene-2-carbonyl chloride

: 155877-92-2
methyl 4-<3-(chloroacetamido) 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxamido>benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / diethyl ether

2: 74 percent / Fe, aq. NH₄Cl / methanol / 3.5 h / Heating

3: 70 percent / pyridine / diethyl ether / 5 h / Ambient temperature

With pyridine; iron; ammonium chloride; In methanol; diethyl ether;
DOI:10.1021/jm00036a017