1-Oxaspiro[5.5]undecan-2-one,10-methyl-7-(1-methylethyl)-,(6S,7S,10R)-(9CI)

Base Information

• Chemical Name: 1-Oxaspiro[5.5]undecan-2-one,10-methyl-7-(1-methylethyl)-,(6S,7S,10R)-(9CI)
• CAS No.: 799268-19-2
• Molecular Formula: C₁₄H₂₄O₂
• Molecular Weight: 224.343
• Mol file: 799268-19-2.mol

Synonyms:1-Oxaspiro[5.5]undecan-2-one,10-methyl-7-(1-methylethyl)-,(6S,7S,10R)-(9CI)

Chemical Property of 1-Oxaspiro[5.5]undecan-2-one,10-methyl-7-(1-methylethyl)-,(6S,7S,10R)-(9CI)

Chemical Property:

• PSA: 26.30000
• LogP: 3.54450

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Oxaspiro[5.5]undecan-2-one,10-methyl-7-(1-methylethyl)-,(6S,7S,10R)-(9CI)

There total 4 articles about 1-Oxaspiro[5.5]undecan-2-one,10-methyl-7-(1-methylethyl)-,(6S,7S,10R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-[(1S,2S,5R)-1-hydroxy-2-isopropyl-5-methylcyclohexyl]-butyric acid pyridin-2-ylmethyl ester → (6S,7S,10R)-7-isopropyl-10-methyl-1-oxaspiro[5.5]undecan-2-one (799268-19-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 0.333333h;

DOI:10.1021/ol048378f

Reference yield: 37.0%

(1S,2S,5R)-1-allyl-2-isopropyl-5-methylcyclohexanol (369651-27-4) + 2-pyridylmethyl formate (401515-97-7) → (1S,2S,5R)-2-isopropyl-5-methyl-1-{1-propen-1-yl}cyclohexan-1-ol (83803-22-9) + (6S,7S,10R)-7-isopropyl-10-methyl-1-oxaspiro[5.5]undecan-2-one (799268-19-2) + 6-isopropyl-3,9-dimethyl-1-oxaspiro[4.5]decan-2-one (799268-21-6) + 4-[(1S,2S,5R)-1-hydroxy-2-isopropyl-5-methylcyclohexyl]-butyric acid pyridin-2-ylmethyl ester

Guidance literature:

With dodecacarbonyl-triangulo-triruthenium; 4-methylmorpholine N-oxide; at 135 ℃; for 12h;

DOI:10.1021/ol048378f

Reference yield: 35.0%

(1S,2S,5R)-1-allyl-2-isopropyl-5-methylcyclohexanol (369651-27-4) + acrylic acid (79-10-7) → (6S*,7S*,10R*)-7-isopropyl-10-methyl-oxaspiro(5.5)undecan-2-one (799268-19-2) + 1-Propyl-neomenthol (18368-88-2,33651-14-8,33651-15-9)

Guidance literature:

With hydrogen; platinum(IV) oxide; ruthenium; In dichloromethane; at 20 ℃; under 760.051 Torr;

DOI:10.1021/ol027347m

upstream raw materials:

(1S,2S,5R)-1-allyl-2-isopropyl-5-methylcyclohexanol

2-pyridylmethyl formate

acrylic acid