4-(3,5-dichlorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Base Information

• Chemical Name: 4-(3,5-dichlorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one
• CAS No.: 1269125-43-0
• Molecular Formula: C₉H₇Cl₂N₃O
• Molecular Weight: 244.08
• Mol file: 1269125-43-0.mol

Synonyms:4-(3,5-dichlorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Chemical Property of 4-(3,5-dichlorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3,5-dichlorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

There total 1 articles about 4-(3,5-dichlorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl 2-(1-ethoxyethylidene)hydrazinecarboxylate (51814-82-5,51814-83-6,58910-28-4) + 3,5-Dichloroaniline (626-43-7) → 4-(3,5-dichlorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (1269125-43-0)

Guidance literature:

In neat (no solvent); at 185 ℃; for 0.166667h; Temperature; Time; Microwave irradiation; Sealed tube;

DOI:10.3184/174751912X13400138806685

Reference yield: 95.0%

4-(3,5-dichlorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (1269125-43-0) + ethyl bromoacetate (105-36-2) → ethyl [4-(3,5-dichlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetate (1403889-24-6)

Guidance literature:

4-(3,5-dichlorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one; With potassium carbonate; In acetone; at 90 ℃; for 0.0833333h; Microwave irradiation; Sealed tube;

ethyl bromoacetate; In acetone; at 90 ℃; for 0.166667h; Temperature; Time; Microwave irradiation; Sealed tube;

DOI:10.3184/174751912X13400138806685

Reference yield: 80.0%

4-Nitrophthalonitrile (31643-49-9) + 4-(3,5-dichlorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (1269125-43-0) → C17H9Cl2N5O (1478498-30-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 96h; Schlenk technique;

DOI:10.1016/j.jorganchem.2013.08.029

upstream raw materials:

ethyl 2-(1-ethoxyethylidene)hydrazinecarboxylate

3,5-Dichloroaniline

Downstream raw materials:

4-(3,5-dichlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

2-[4-(3,5-dichlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetohydrazide

ethyl [4-(3,5-dichlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetate

C₁₇H₉Cl₂N₅O