(S)-tert-butyl 1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine-4(5H)-carboxylate

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Chemical Name:(S)-tert-butyl 1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine-4(5H)-carboxylate
CAS No.:1278520-74-3
Molecular Formula:C₃₅H₃₄ClN₃O₅
Molecular Weight:612.125
Hs Code.:

Synonyms:(S)-tert-butyl 1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine-4(5H)-carboxylate

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Chemical Property of (S)-tert-butyl 1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine-4(5H)-carboxylate

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Technology Process of (S)-tert-butyl 1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine-4(5H)-carboxylate

There total 5 articles about (S)-tert-butyl 1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine-4(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 4-[([1,1,-Biphenyl]-2-carbonyl)amino]-2-chlorobenzoic Acid

: 886225-47-4
(S)-tert-butyl 3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine-4(5H)-carboxylate

: 1278520-74-3
(S)-tert-butyl 1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine-4(5H)-carboxylate

Guidance literature:: 4-[([1,1,-Biphenyl]-2-carbonyl)amino]-2-chlorobenzoic Acid; With thionyl chloride; In acetic acid butyl ester; at 64 ℃; for 1.5h;

(S)-tert-butyl 3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine-4(5H)-carboxylate; In acetone; at 20 ℃; Cooling with ice;

Reference yield:

: 947-84-2
2-Biphenylcarboxylic acid

: 1278520-74-3
(S)-tert-butyl 1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine-4(5H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 5 - 20 °C

2.1: chloro-trimethyl-silane; pyridine / toluene / 0.5 h / 5 °C

2.2: 2.5 h / 5 °C

2.3: 35 - 85 °C

3.1: thionyl chloride / acetic acid butyl ester / 1.5 h / 64 °C

3.2: 20 °C / Cooling with ice

With pyridine; chloro-trimethyl-silane; thionyl chloride; oxalyl dichloride; N,N-dimethyl-formamide; In acetic acid butyl ester; toluene;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1278520-74-3
(S)-tert-butyl 1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine-4(5H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / ethyl acetate; water / Reflux

2.1: thionyl chloride / acetic acid butyl ester / 1.5 h / 64 °C

2.2: 20 °C / Cooling with ice

With thionyl chloride; triethylamine; In acetic acid butyl ester; water; ethyl acetate;