[4-[(tert-Butyldimethylsiloxy)methyl]phenyl]-(pyridin-3-yl)carbinol

Base Information

• Chemical Name: [4-[(tert-Butyldimethylsiloxy)methyl]phenyl]-(pyridin-3-yl)carbinol
• CAS No.: 161607-38-1
• Molecular Formula: C₁₉H₂₇NO₂Si
• Molecular Weight: 329.514
• Mol file: 161607-38-1.mol

Synonyms:[4-[(tert-Butyldimethylsiloxy)methyl]phenyl]-(pyridin-3-yl)carbinol

Chemical Property of [4-[(tert-Butyldimethylsiloxy)methyl]phenyl]-(pyridin-3-yl)carbinol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-[(tert-Butyldimethylsiloxy)methyl]phenyl]-(pyridin-3-yl)carbinol

There total 6 articles about [4-[(tert-Butyldimethylsiloxy)methyl]phenyl]-(pyridin-3-yl)carbinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-pyridyllithium (17624-36-1) + 3-Bromopyridine (626-55-1,163928-56-1) + MeOH-CH2Cl2afforded → [4-[(tert-Butyldimethylsiloxy)methyl]phenyl]-(pyridin-3-yl)carbinol (161607-38-1)

Guidance literature:

With n-butyllithium; benzaldehyde; In diethyl ether;

Reference yield:

p-xylylene glycol (589-29-7) → [4-[(tert-Butyldimethylsiloxy)methyl]phenyl]-(pyridin-3-yl)carbinol (161607-38-1)

Guidance literature:

Multi-step reaction with 3 steps

1: imidazole / CH₂Cl₂

2: MnO₂ / tetrahydrofuran / Heating

3: diethyl ether / -78 °C

With 1H-imidazole; manganese(IV) oxide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/S0960-894X(98)00353-9

Reference yield:

[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenyl]methanol (118992-89-5) → [4-[(tert-Butyldimethylsiloxy)methyl]phenyl]-(pyridin-3-yl)carbinol (161607-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: MnO₂ / tetrahydrofuran / Heating

2: diethyl ether / -78 °C

With manganese(IV) oxide; In tetrahydrofuran; diethyl ether;

DOI:10.1016/S0960-894X(98)00353-9

upstream raw materials:

3-pyridyllithium

4-((tert-butyldimethylsilyloxy)methyl)benzaldehyde

p-xylylene glycol

[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenyl]methanol

Downstream raw materials:

4-[(tert-Butyldimethylsiloxy)methyl]phenyl pyridin-3-yl ketone