N-(1-methyl-1-(2,4-di(4-methoxyphenylthio)phenyl)ethyl)picolinamide

Base Information

• Chemical Name: N-(1-methyl-1-(2,4-di(4-methoxyphenylthio)phenyl)ethyl)picolinamide
• CAS No.: 1404616-87-0
• Molecular Formula: C₂₉H₂₈N₂O₃S₂
• Molecular Weight: 516.685
• Mol file: 1404616-87-0.mol

Synonyms:N-(1-methyl-1-(2,4-di(4-methoxyphenylthio)phenyl)ethyl)picolinamide

Chemical Property of N-(1-methyl-1-(2,4-di(4-methoxyphenylthio)phenyl)ethyl)picolinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-methyl-1-(2,4-di(4-methoxyphenylthio)phenyl)ethyl)picolinamide

There total 2 articles about N-(1-methyl-1-(2,4-di(4-methoxyphenylthio)phenyl)ethyl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4,4'-dimethoxyphenyl disulfide (5335-87-5) + N-(1-methyl-1-phenylethyl)picolinamide (1404616-63-2) → N-(1-methyl-1-(2-(4-methoxyphenylthio)phenyl)ethyl)picolinamide (1404616-86-9) + N-(1-methyl-1-(2,4-di(4-methoxyphenylthio)phenyl)ethyl)picolinamide (1404616-87-0)

Guidance literature:

With copper diacetate; potassium carbonate; In dimethyl sulfoxide; at 130 ℃; for 24h;

DOI:10.1021/ja3092278

Reference yield:

2-Picolinic acid (98-98-6) + 2-phenyl-2-propylamine (585-32-0) → N-(1-methyl-1-(2-(4-methoxyphenylthio)phenyl)ethyl)picolinamide (1404616-86-9) + N-(1-methyl-1-(2,4-di(4-methoxyphenylthio)phenyl)ethyl)picolinamide (1404616-87-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: copper diacetate; potassium carbonate / dimethyl sulfoxide / 24 h / 130 °C

With copper diacetate; potassium carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/ja3092278

upstream raw materials:

2-Picolinic acid

2-phenyl-2-propylamine

4,4'-dimethoxyphenyl disulfide

N-(1-methyl-1-phenylethyl)picolinamide