1,3-bis((4-((1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzene

Base Information

• Chemical Name: 1,3-bis((4-((1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzene
• CAS No.: 1609103-25-4
• Molecular Formula: C₂₀H₂₀N₁₀
• Molecular Weight: 400.446
• Mol file: 1609103-25-4.mol

Synonyms:1,3-bis((4-((1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzene

Chemical Property of 1,3-bis((4-((1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-bis((4-((1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzene

There total 2 articles about 1,3-bis((4-((1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(prop-2-yn-1-yl)-1H-pyrazole (20306-74-5) + 1,3-bis(azidomethyl)benzene (102437-80-9) → 1,3-bis((4-((1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzene (1609103-25-4)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In dimethyl sulfoxide; at 20 ℃; Inert atmosphere;

DOI:10.1039/c3dt53295j

Reference yield:

1,3-bis-(bromomethyl)benzene (626-15-3) → 1,3-bis((4-((1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzene (1609103-25-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / dimethyl sulfoxide / 20 °C / Inert atmosphere; Schlenk technique

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dimethyl sulfoxide / 20 °C / Inert atmosphere

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In dimethyl sulfoxide;

DOI:10.1039/c3dt53295j

Reference yield: 92.0%

di(rhodium)tetracarbonyl dichloride + 1,3-bis((4-((1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzene (1609103-25-4) + sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate (79060-88-1) → [(rhodium(I)(carbonyl)2)2(1,2-bis((4-((1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzene)][tetrakis(3,5-bis(trifluoromethyl)phenyl)borate]2

Guidance literature:

di(rhodium)tetracarbonyl dichloride; 1,3-bis((4-((1H-pyrazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzene; In dichloromethane; at 20 ℃; for 0.75h; Inert atmosphere; Schlenk technique;

sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c3dt53295j

upstream raw materials:

1-(prop-2-yn-1-yl)-1H-pyrazole

1,3-bis(azidomethyl)benzene

1,3-bis-(bromomethyl)benzene