888330-57-2Relevant academic research and scientific papers
A highly enantio- and diastereoselective Cu-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with nitroalkenes
Yan, Xiao-Xia,Peng, Qian,Zhang, Yan,Zhang, Kai,Hong, Wei,Hou, Xue-Long,Wu, Yun-Dong
, p. 1979 - 1983 (2006)
(Chemical Equation Presented) Electronic properties of the ligands switch the diastereoselectivity in the Cu-catalyzed 1,3-dipolar cycloaddition of azomethine ylides to nitroalkenes: exo- or endopyrrolidines were obtained with high diastereo- and enantios
Nitroprolinates as Nucleophiles in Michael-type Additions and Acylations. Synthesis of Enantiomerically Enriched Fused Amino-pyrrolidino-[1,2-a]pyrazinones and -diketopiperazines
García-Mingüens, Eduardo,Selva, Verónica,Larra?aga, Olatz,Nájera, Carmen,Sansano, José M.,de Cózar, Abel
, p. 2014 - 2021 (2020/02/20)
The enantioselective formation of nitroprolinates followed by diastereoselective Michael-type addition onto a second unit of the nitro alkene is studied. The reaction occurred in a one pot-sequential process controlled by the chiral phosphoramidite?silver benzoate complex. The origin of the high diastereoselectivity is studied by DFT computational analysis where the crucial effect of the benzoic acid is justified. The employment of this strategy to the preparation of pyrazine-2-ones is also surveyed, as well as the preparation of diketopiperazines from enantiomerically enriched exo-prolinates using conventional N-acylation-amination-cyclization steps.
Bifunctional AgOAc/ThioClickFerrophos catalyzed asymmetric 1,3-dipolar cycloaddition reaction of azomethine ylides to nitroalkenes
Kimura, Midori,Matsuda, Yukiko,Koizumi, Akihiro,Tokumitsu, Chihiro,Tokoro, Yuichiro,Fukuzawa, Shin-Ichi
, p. 2666 - 2670 (2016/05/10)
AgOAc/ThioClickFerrophos (TCF) complex catalyzed the 1,3-dipolar cycloaddition of azomethine ylides (glycine imino ester) to nitroalkenes. The corresponding endo-cycloadducts (88:12-98:2 endo/exo) were afforded in good yields with high enantioselectivitie
Remote substituent effects on the stereoselectivity and organocatalytic activity of densely substituted unnatural proline esters in aldol reactions
De Gracia Retamosa, María,De C?zar, Abel,Sánchez, Mirian,Miranda, José I.,Sansano, José M.,Castell?, Luis M.,Nájera, Carmen,Jiménez, Ana I.,Sayago, Francisco J.,Cativiela, Carlos,Cossío, Fernando P.
supporting information, p. 2503 - 2516 (2015/04/22)
The organocatalytic activities of highly substituted proline esters obtained through asymmetric [3+2] cycloadditions of azomethine ylides derived from glycine iminoesters have been analyzed by 19F NMR and through kinetic isotope effects. Kineti
Phosphoramidite-Cu(OTf)2 complexes as chiral catalysts for 1,3-dipolar cycloaddition of iminoesters and nitroalkenes
Castello, Luis M.,Najera, Carmen,Sansano, Jose M.,Larranaga, Olatz,Cozar, Abel De,Cossio, Fernando P.
supporting information, p. 2902 - 2905 (2013/07/26)
Chiral complexes formed by phosphoramidites such as (Sa,R,R)-9 and Cu(OTf)2 are excellent catalysts for the general 1,3-dipolar cycloaddition between azomethine ylides and nitroalkenes affording the corresponding tetrasubstituted pro
NOVEL PYRROLE DERIVATIVES WITH HISTONE DEACETYLASE INHIBITOR ACTIVITY
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Page/Page column 11-12, (2008/12/07)
The invention describes new compounds derived from formula I pyrroles, methods for obtaining them and their application as drugs in pharmaceutical compositions for the treatment of cancer due to their inhibitory activity on certain histone deacetylases.
