6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]ethyl]-2-phenyl-pyrimidine

Base Information

Chemical Name:6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]ethyl]-2-phenyl-pyrimidine
CAS No.:1403989-52-5
Molecular Formula:C₃₅H₃₉N₃O₇
Molecular Weight:613.711
Hs Code.:

6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]ethyl]-2-phenyl-pyrimidine

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Chemical Property of 6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]ethyl]-2-phenyl-pyrimidine

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Technology Process of 6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]ethyl]-2-phenyl-pyrimidine

There total 7 articles about 6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]ethyl]-2-phenyl-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1403989-48-9
(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxy-5,5,5-tris(dimethylamino)pent-3-yne

: 1670-14-0
benzamidine monohydrochloride

: 1403989-52-5
6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]ethyl]-2-phenyl-pyrimidine

Guidance literature:: benzamidine monohydrochloride; With sodium; In ethanol; at 20 ℃; for 0.5h;

(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxy-5,5,5-tris(dimethylamino)pent-3-yne; In tetrahydrofuran; ethanol; at 65 ℃; for 3h;
DOI:10.5560/ZNB.2012-0108

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1403989-52-5
6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]ethyl]-2-phenyl-pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / 20 - 70 °C

2.1: sodium periodate / 1,4-dioxane; water / 48 h / 20 °C

3.1: zinc / toluene; N,N-dimethyl-formamide; diethyl ether / 20 - 35 °C

4.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 3 h / 20 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / -40 - 20 °C

5.2: 168 h / 20 °C / Inert atmosphere

6.1: sodium / ethanol / 0.5 h / 20 °C

6.2: 3 h / 65 °C

With sodium periodate; n-butyllithium; sodium; sodium hydride; acetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; hexane; water; N,N-dimethyl-formamide; toluene; paraffin oil; 3.1: |Barbier Coupling Reaction;
DOI:10.5560/ZNB.2012-0108

Reference yield:

: 1403989-46-7
(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxybut-3-yne

: 1403989-52-5
6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]ethyl]-2-phenyl-pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -40 - 20 °C

1.2: 168 h / 20 °C / Inert atmosphere

2.1: sodium / ethanol / 0.5 h / 20 °C

2.2: 3 h / 65 °C

With n-butyllithium; sodium; In tetrahydrofuran; ethanol; hexane;
DOI:10.5560/ZNB.2012-0108