(R,S)-2-((benzyloxycarbonylamino)(4-fluorophenyl)methyl)-quinazolin-4-yl-2,4,6-triisopropylbenzenesulfonate

Base Information

Chemical Name:(R,S)-2-((benzyloxycarbonylamino)(4-fluorophenyl)methyl)-quinazolin-4-yl-2,4,6-triisopropylbenzenesulfonate
CAS No.:1241914-95-3
Molecular Formula:C₃₈H₄₀FN₃O₅S
Molecular Weight:669.817
Hs Code.:

Synonyms:(R,S)-2-((benzyloxycarbonylamino)(4-fluorophenyl)methyl)-quinazolin-4-yl-2,4,6-triisopropylbenzenesulfonate

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Chemical Property of (R,S)-2-((benzyloxycarbonylamino)(4-fluorophenyl)methyl)-quinazolin-4-yl-2,4,6-triisopropylbenzenesulfonate

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Technology Process of (R,S)-2-((benzyloxycarbonylamino)(4-fluorophenyl)methyl)-quinazolin-4-yl-2,4,6-triisopropylbenzenesulfonate

There total 2 articles about (R,S)-2-((benzyloxycarbonylamino)(4-fluorophenyl)methyl)-quinazolin-4-yl-2,4,6-triisopropylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: 1360652-10-3
C₂₃H₁₈FN₃O₃

: 1241914-95-3
(R,S)-2-((benzyloxycarbonylamino)(4-fluorophenyl)methyl)-quinazolin-4-yl-2,4,6-triisopropylbenzenesulfonate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield: 75.0%

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: (R,S)-(4-fluorophenyl)(4-hydroxyquinazolin-2-yl)methylcarbamate

: 1241914-95-3
(R,S)-2-((benzyloxycarbonylamino)(4-fluorophenyl)methyl)-quinazolin-4-yl-2,4,6-triisopropylbenzenesulfonate

Guidance literature:: With dmap; triethanolamine; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield: 9.0%

: 31230-17-8
3-methyl-5-aminopyrazole

: 1241914-95-3
(R,S)-2-((benzyloxycarbonylamino)(4-fluorophenyl)methyl)-quinazolin-4-yl-2,4,6-triisopropylbenzenesulfonate

: 64-19-7,77671-22-8
acetic acid

: 1360652-11-4
(R,S)-2-(amino(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine acetate

Guidance literature:: 3-methyl-5-aminopyrazole; (R,S)-2-((benzyloxycarbonylamino)(4-fluorophenyl)methyl)-quinazolin-4-yl-2,4,6-triisopropylbenzenesulfonate; With potassium iodide; In ISOPROPYLAMIDE; at 55 ℃; for 4h;

With hydrogen; 10% Pd(OH)2/C; In methanol; for 6h;

acetic acid; In water; acetonitrile;