C₁₃H₁₄F₅NOS

Base Information

• Chemical Name: C₁₃H₁₄F₅NOS
• CAS No.: 1453070-25-1
• Molecular Formula: C₁₃H₁₄F₅NOS
• Molecular Weight: 327.318
• Mol file: 1453070-25-1.mol

Synonyms:C₁₃H₁₄F₅NOS

Chemical Property of C₁₃H₁₄F₅NOS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₃H₁₄F₅NOS

There total 7 articles about C₁₃H₁₄F₅NOS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3-(difluoromethyl)-5-(trifluoromethyl)benzaldehyde (1453070-24-0) + (S)-2-methylpropane-2-sulfinamide (343338-28-3) → C13H14F5NOS (1453070-25-1)

Guidance literature:

With titanium(IV) isopropylate; In tetrahydrofuran; at 0 - 20 ℃; for 20h;

Reference yield:

3-bromo-5-(trifluoromethyl)benzoic acid (328-67-6) → C13H14F5NOS (1453070-25-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 °C

2.1: triethylamine / dichloromethane / 1 h / 0 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

4.1: diethylamino-sulfur trifluoride / dichloromethane / 1.5 h / 0 °C

5.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1.25 h / 110 °C / Inert atmosphere

6.1: ozone; oxygen / dichloromethane / -78 °C

6.2: 20 h / 20 °C / Inert atmosphere

7.1: titanium(IV) isopropylate / tetrahydrofuran / 20 h / 0 - 20 °C

With titanium(IV) isopropylate; bis-triphenylphosphine-palladium(II) chloride; oxalyl dichloride; diethylamino-sulfur trifluoride; oxygen; diisobutylaluminium hydride; ozone; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;

Reference yield:

3-bromo-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide (880652-44-8) → C13H14F5NOS (1453070-25-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane / 1.5 h / 0 °C

3.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1.25 h / 110 °C / Inert atmosphere

4.1: ozone; oxygen / dichloromethane / -78 °C

4.2: 20 h / 20 °C / Inert atmosphere

5.1: titanium(IV) isopropylate / tetrahydrofuran / 20 h / 0 - 20 °C

With titanium(IV) isopropylate; bis-triphenylphosphine-palladium(II) chloride; diethylamino-sulfur trifluoride; oxygen; diisobutylaluminium hydride; ozone; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;

upstream raw materials:

3-bromo-5-(trifluoromethyl)benzoic acid

3-bromo-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide

3-bromo-5-(trifluoromethyl)benzoyl chloride

3-bromo-5-(trifluoromethyl)benzaldehyde

Downstream raw materials:

(S)-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

(S)-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

(R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)-N-methylethanamine

(1S,8aS)-7,7-diallyl-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide