N-((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)(2Z)-3-methyl-N-methylbut-2-enamide

Base Information

Chemical Name:N-((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)(2Z)-3-methyl-N-methylbut-2-enamide
CAS No.:332842-76-9
Molecular Formula:C₁₅H₂₁NO₂
Molecular Weight:247.337
Hs Code.:

Synonyms:N-((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)(2Z)-3-methyl-N-methylbut-2-enamide

Suppliers and Price of N-((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)(2Z)-3-methyl-N-methylbut-2-enamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)(2Z)-3-methyl-N-methylbut-2-enamide

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Technology Process of N-((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)(2Z)-3-methyl-N-methylbut-2-enamide

There total 1 articles about N-((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)(2Z)-3-methyl-N-methylbut-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 3350-78-5
3,3-Dimethylacryloyl chloride

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 121-44-8
triethylamine

: 332842-76-9
N-((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)(2Z)-3-methyl-N-methylbut-2-enamide

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 0.333333h;
DOI:10.1021/ol015531m

Reference yield: 93.0%

: 75-03-6
ethyl iodide

: 332842-76-9
N-((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)(2Z)-3-methyl-N-methylbut-2-enamide

: 332842-77-0
(2S)-N-((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)-2-ethyl-3-methyl-N-methylbut-3-enamide

Guidance literature:: N-((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)(2Z)-3-methyl-N-methylbut-2-enamide; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; at -78 - 20 ℃; for 1.5h;

ethyl iodide; In tetrahydrofuran; at 0 ℃; for 0.5h; Further stages.;
DOI:10.1021/ol015531m

Reference yield:

: 332842-76-9
N-((1S,2S)-2-hydroxy-1-methyl-2-phenylethyl)(2Z)-3-methyl-N-methylbut-2-enamide

: 332842-78-1
1-((S)-2-Ethyl-3-methyl-but-3-enyloxymethyl)-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiCl; diisopropylamide; n-BuLi / tetrahydrofuran; various solvent(s) / 1.5 h / -78 - 20 °C

1.2: 93 percent / tetrahydrofuran; various solvent(s) / 0.5 h / 0 °C

2.1: LiNH₂*BH₃ / tetrahydrofuran / 3.17 h

3.1: KH / various solvents / 5 h / -15 - 20 °C

With n-butyllithium; lithium amidotrihydroborate; potassium hydride; diisopropylamine; lithium chloride; In tetrahydrofuran; various solvents;
DOI:10.1021/ol015531m