2-[4-(4-fluoro-3-methylphenyl)-2-piperidin-4-yl-imidazol-1-yl]ethyl-dimethylamine

Base Information

Chemical Name:2-[4-(4-fluoro-3-methylphenyl)-2-piperidin-4-yl-imidazol-1-yl]ethyl-dimethylamine
CAS No.:1428253-14-8
Molecular Formula:C₁₉H₂₇FN₄
Molecular Weight:330.449
Hs Code.:

Synonyms:2-[4-(4-fluoro-3-methylphenyl)-2-piperidin-4-yl-imidazol-1-yl]ethyl-dimethylamine

Suppliers and Price of 2-[4-(4-fluoro-3-methylphenyl)-2-piperidin-4-yl-imidazol-1-yl]ethyl-dimethylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[4-(4-fluoro-3-methylphenyl)-2-piperidin-4-yl-imidazol-1-yl]ethyl-dimethylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[4-(4-fluoro-3-methylphenyl)-2-piperidin-4-yl-imidazol-1-yl]ethyl-dimethylamine

There total 5 articles about 2-[4-(4-fluoro-3-methylphenyl)-2-piperidin-4-yl-imidazol-1-yl]ethyl-dimethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428252-95-2
4-[4-(4-fluoro-3-methylphenyl)-1-(2-hydroxyethyl)-1H-imidazol-2-yl]piperidine-1-carboxylic acid tert-butyl ester

: 124-40-3
dimethyl amine

: 1428253-14-8
2-[4-(4-fluoro-3-methylphenyl)-2-piperidin-4-yl-imidazol-1-yl]ethyl-dimethylamine

Guidance literature:: 4-[4-(4-fluoro-3-methylphenyl)-1-(2-hydroxyethyl)-1H-imidazol-2-yl]piperidine-1-carboxylic acid tert-butyl ester; With triethylamine; p-toluenesulfonyl chloride; In dichloromethane; at -78 - 20 ℃;

dimethyl amine; In tetrahydrofuran; Sealed tube;

With trifluoroacetic acid; for 0.333333h;

Reference yield:

: 1428252-94-1
tert-butyl 4-(4-bromo-1H-imidazol-2-yl)piperidine-1-carboxylate

: 1428253-14-8
2-[4-(4-fluoro-3-methylphenyl)-2-piperidin-4-yl-imidazol-1-yl]ethyl-dimethylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 1.5 h

1.2: 4 h

1.3: 0.33 h / 20 °C

2.1: bis-tributylphosphine palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 5 h / 70 °C / Sealed tube

3.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / -78 - 20 °C

3.2: Sealed tube

3.3: 0.33 h

With bis-tributylphosphine palladium⁽⁰⁾; caesium carbonate; triethylamine; p-toluenesulfonyl chloride; potassium hydroxide; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 137076-22-3
tert butyl 4-formylpiperidine-1-carboxylate

: 1428253-14-8
2-[4-(4-fluoro-3-methylphenyl)-2-piperidin-4-yl-imidazol-1-yl]ethyl-dimethylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium hydroxide / methanol; water / 1 h / 20 °C

2.1: N-Bromosuccinimide / tetrahydrofuran / 0.25 h / -46 °C

3.1: potassium hydroxide / dimethyl sulfoxide / 1.5 h

3.2: 4 h

3.3: 0.33 h / 20 °C

4.1: bis-tributylphosphine palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 5 h / 70 °C / Sealed tube

5.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / -78 - 20 °C

5.2: Sealed tube

5.3: 0.33 h

With ammonium hydroxide; N-Bromosuccinimide; bis-tributylphosphine palladium⁽⁰⁾; caesium carbonate; triethylamine; p-toluenesulfonyl chloride; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide;